FB2026_02 , released June 18, 2026
Allele: Dmel\stl2
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General Information
Symbol
Dmel\stl2
Species
D. melanogaster
Name
FlyBase ID
FBal0016195
Feature type
allele
Associated gene
Dmel\stl
Associated Insertion(s)
Carried in Construct
Also Known As
stlAWK26
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Schupbach and Wieschaus, 1991)
Progenitor genotype
Cytology
Description

Amino acid replacement (Q to stop) at a position that corresponds to residue 101 in the B isoform, and residue 146 in the C isoform (not applicable to the A isoform). Also, an amino acid replacement (T to I) at a position that corresponds to residue 99 in the A isoform (not applicable to the B and C isoforms).

(Ozdowski et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:22,812,338..22,812,338 [+]
Nucleotide change:

C22812338T

Amino acid change:

Q146term | stl-PC; Q146term | stl-PE

Reported amino acid change:

Q146term

Reported_genomic_loc:

2R_r5:18699843..18699843

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. One of two amino acid changes observed in mutant. Amino acid change only applies to two isoforms since the short form starts downstream of the nonsense mutation.

(Ozdowski et al., 2009)
point_mutation
2R:22,813,408..22,813,408 [+]
Nucleotide change:

C22813408T

Amino acid change:

T445I | stl-PC; T445I | stl-PE

Reported amino acid change:

T99I

Reported_genomic_loc:

2R_r5:18700913..18700913

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. One of two amino acid changes observed in mutant. Only applies to the shortest isoform since translation is terminated before this residue in other isoforms due to the earlier nonsense mutation.

(Ozdowski et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      stl2 and stl2/stl4 mutant embryos display significantly faster dorsal migration of the v'ch1 sensory neuron during stages 15-17, to its target the lch5 chordotonal organ cluster, as compared to wild type, and no over-migration past its target.

      (Lhamo and Ismat, 2015)

      Mutant ovarioles in adult females lack the interfollicular stalks that normally separate adjacent wild-type follicles. This phenotype results from failed follicle individualisation, rather than from persistent germline cell division, because mutant ovarioles contain germ cells at varying stages of maturation and groups of 16 interconnected germ cells that would correspond to a single germline cyst in wild-type are still recognisable. Degeneration is seen in the mutant ovarioles, which increases with age, and both germline and somatic cells appear to degenerate.

      (Willard et al., 2004)

      stl4/stl2 females lack morphological stalks in the ovary.

      (Tworoger et al., 1999)

      Abnormal numbers of nurse cells and tumorous egg chambers.

      (Schupbach and Wieschaus, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      AWK26
      (Tworoger et al., 1999)
      stl2
      stlAWK26
      (Willard et al., 2004, Schupbach and Wieschaus, 1991)
      stlAWK
      stlawk26
      (Lhamo and Ismat, 2015, Ozdowski et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)