FlyBase Allele Report: Dmel\Su(var)2-1[210]

General Information

Symbol

Dmel\Su(var)2-1²¹⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0016498

Feature type

allele

Associated gene

Dmel\Su(var)2-1

Associated Insertion(s)

Carried in Construct

Also Known As

Su(var)210

Key Links

Allele class

antimorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Sinclair et al., 1992)

Mutagen

ethyl methanesulfonate

(Sinclair et al., 1992, Hearn et al., 1991, Sinclair et al., 1983)

Progenitor genotype

Cytology

Description

Frameshift or stop mutation starting at codon 458.

(Walther et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

One copy of Su(var)2-1^210-1 strongly suppresses position effect variegation (PEV) at the w locus caused by In(1)w^m4.

One copy of Su(var)2-1^210-1 is unable to suppress the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

(Doheny et al., 2008)

Dominantly suppresses position effect variegation (PEV) at the w locus caused by In(1)w^m4, PEV at the bw locus caused by In(2R)bw^VDe2 and PEV at the B locus caused by Dp(1;Y)B^SCV.

(Sinclair et al., 1998)

No maternal effects seen in w⁺ eye pigment levels in non-suppressor bearing offspring of Su(var)2-1 females. Removal of segments of heterochromatin from the genome by loss of the Y chromosome abolishes the suppression of the position effect variegation phenotype. The extent of hemizygous lethality is dramatically enhanced in the presence of extra heterochromatin (attachedXX/Y females) whereas the lethality did not occur in the absence of the Y (X/O males). The effect of the Su(var)2-1^210-1 allele is slightly reduced in heterozygotes with Df(2R)M41A10 (which lacks 2R heterochromatin).

(Sinclair et al., 1992)

Does not enhance variegation at the lt locus.

(Hearn et al., 1991)

Su(var)2-1^210-1; Dp(2;2)Mdh3 double mutants display reductions in eye pigmentation.

(Sinclair et al., 1989)

Dominant suppressor of position effect variegation at the w locus caused by In(1)w^m4.

(Sinclair et al., 1983)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Originally isolated as a dominant suppressor of the w⁺ gene on In(1)w^m4.

(Hearn et al., 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

2-1²¹⁰

(Walther et al., 2020)

Su(var)2-1^210-1

Su(var)2-1²¹⁰

Su(var)210

(Sinclair et al., 1998, Lindsley and Zimm, 1992, Hearn et al., 1991, Hayashi et al., 1990, Sinclair et al., 1989, Sinclair et al., 1983)

Su(var)210¹

(Lindsley and Zimm, 1992)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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