FlyBase Gene Report: Dmel\Su(var)2-1

General Information

Symbol

Dmel\Su(var)2-1

Species

D. melanogaster

Name

Suppressor of variegation 2-1

Annotation Symbol

CG5694

Feature Type

protein_coding_gene

FlyBase ID

FBgn0290203

Gene Model Status

Current

Stock Availability

21 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Red Book
Interactive Fly

Also Known As

Su-var(2)1, Suvar(2)1, Su(var)b¹⁰¹, ova, ovaries absent

Key Links

Genomic Location

Cytogenetic map

31B1-31B1

Sequence location

2L:10,227,760..10,231,692 [-]

Recombination map

2-40

RefSeq locus

NT_033779 REGION:10227760..10231692

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN001838773

(GO Reference Genome Project, 2011-)

enables DNA-binding transcription factor activity

inferred from electronic annotation with InterPro:IPR039142

(InterPro Project Members, 2004-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN001838773

(GO Reference Genome Project, 2011-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of transcription by RNA polymerase II

inferred from electronic annotation with InterPro:IPR039142

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN001838773

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN001838773

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Su(var)2-1

Su(var)2-1/+ but not Su(var)2-1/+/+ display nearly normal amounts of eye pigment in In(1)wm4 flies. Homozygous viable; females sterile; do not produce eggs. Survival reduced by the presence of the Y chromosome or by administration of sodium n-butyrate, an inhibitor of histone deacetylation (Reuter, Dorn, and Hoffmann, 1982, Mol. Gen. Genet. 188: 480-85). Exhibits significant hyperacetylation of histone H4 and increased accessibility of chromatin to endogenous nuclease, suggesting a defect in chromosome condensation (Dorn, Heymann, Lindigkeit, and Reuter, 1986, Chromosoma 93: 398-403).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Su(var)2-1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VL20)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Su(var)2-1-RA

FBtr0079953

NM_135516

2132

623

Su(var)2-1-RB

FBtr0079954

NM_164894

2388

623

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Su(var)2-1-PA

FBpp0079543

71.9

623

8.17

FBpp0079544

71.9

623

8.17

Q9VL20

NP_723535

AAN10725

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

623 aa isoforms: Su(var)2-1-PA, Su(var)2-1-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(var)2-1 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.72

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Su(var)2-1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Su(var)2-1

View exonic expression by tissue for Dmel\Su(var)2-1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34362/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0290203

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0290203

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 45 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 19 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Su(var)2-1

Transgenic constructs containing regulatory region of Su(var)2-1

Aberrations (Deficiencies and Duplications) ( 17 )

Inferred from experimentation ( 17 )

Gene duplicated in

Dp(2;2)10

(Westphal and Reuter, 2002, Wustmann et al., 1989)

Dp(2;2)92

(Wustmann et al., 1989)

Dp(2;2)165

(Wustmann et al., 1989)

Gene disrupted in

Df(2L)Exel6026

(Ryder, 2004.4.26)

Df(2L)Exel8024

(Ryder, 2004.4.26)

Df(2L)J2

(Clegg et al., 1993, Sinclair et al., 1992)

Df(2L)J27

(Sinclair et al., 1992)

Df(2L)J77

(Sinclair et al., 1992)

Df(2L)TE31Aa-1

(Wustmann et al., 1989)

Gene not disrupted in

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | male | recessive

lethal | male limited (with Su(var)2-1^ova-1)

Su(var)2-1^ova-4

lethal | male limited (with Su(var)2-1^ova-4)

Su(var)2-1^ova-1

lethal | recessive

partially lethal | female

Su(var)2-1⁰¹

partially lethal - majority die

Su(var)2-1⁰¹

partially lethal - majority die (with Df(YL)S6)

Su(var)2-1⁰¹

partially lethal - majority die (with Df(YS)S12)

Su(var)2-1⁰¹

partially lethal - majority die | female | recessive

Su(var)2-1^ova-1

partially lethal - majority live (with Df(YL)S10)

Su(var)2-1⁰¹

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Su(var)2-1^GD11738

viable, with Scer\GAL4^Mef2.PR

Su(var)2-1^GD11738

viable, with Scer\GAL4^pnr-MD237

Su(var)2-1^GD11738

viable | female (with Su(var)2-1^ova-1)

Su(var)2-1^ova-4

viable | female (with Su(var)2-1^ova-4)

Su(var)2-1^ova-1

Sterility

Allele

female fertile

female fertile, with Scer\GAL4^nanos.PG

Su(var)2-1^GL00615

female semi-sterile, with Scer\GAL4^nanos.PG

Su(var)2-1^KK110959

female sterile

female sterile (with Df(2L)ED721)

female sterile (with Su(var)2-1^ova-1)

Su(var)2-1^ova-4

female sterile (with Su(var)2-1^ova-4)

Su(var)2-1^ova-1

female sterile | recessive

Other Phenotypes

Allele

abnormal cell number | oogenesis (with Su(var)2-1^ova-1)

Su(var)2-1^ova-4

abnormal cell number | oogenesis (with Su(var)2-1^ova-4)

Su(var)2-1^ova-1

abnormal cell number | oogenesis | recessive

Su(var)2-1^ova-1

abnormal size | adult stage | female

abnormal size | adult stage | female (with Su(var)2-1^ova-1)

Su(var)2-1^ova-4

abnormal size | adult stage | female (with Su(var)2-1^ova-4)

Su(var)2-1^ova-1

decreased fecundity | female

enhancer of variegation, with In(1)w^m4h

Su(var)2-1^sfGFP-TVPTBF

increased cell number | oogenesis, with Scer\GAL4^C587

Su(var)2-1^KK110959

majority die during embryonic stage

Su(var)2-1⁰¹

neoplasia | oogenesis (with Su(var)2-1^ova-1)

Su(var)2-1^ova-4

neoplasia | oogenesis (with Su(var)2-1^ova-4)

Su(var)2-1^ova-1

neoplasia | oogenesis | recessive

Su(var)2-1^ova-1

non-suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

non-suppressor of variegation | dominant, with P{hsp26-pt-T}118E-10

Su(var)2-1⁰¹

suppressor of variegation, with In(1)w^m4h

Su(var)2-1⁰¹

suppressor of variegation (with Su(var)2-1^ova-1), with P{hsp26-pt-T}39C-72

Su(var)2-1^ova-4

suppressor of variegation (with Su(var)2-1^ova-1), with P{hsp26-pt-T}118E-10

Su(var)2-1^ova-4

suppressor of variegation (with Su(var)2-1^ova-1), with P{hsp26-pt-T}Dyrk3^118E-15

Su(var)2-1^ova-4

suppressor of variegation (with Su(var)2-1^ova-1), with P{hsp26-pt-T}Syt7^6-M193

Su(var)2-1^ova-4

suppressor of variegation (with Su(var)2-1^ova-4), with P{hsp26-pt-T}39C-72

Su(var)2-1^ova-1

suppressor of variegation (with Su(var)2-1^ova-4), with P{hsp26-pt-T}118E-10

Su(var)2-1^ova-1

suppressor of variegation (with Su(var)2-1^ova-4), with P{hsp26-pt-T}Dyrk3^118E-15

Su(var)2-1^ova-1

suppressor of variegation (with Su(var)2-1^ova-4), with P{hsp26-pt-T}Syt7^6-M193

Su(var)2-1^ova-1

suppressor of variegation | dominant

Su(var)2-1⁰¹

suppressor of variegation | dominant, with Dp(1;3)w^vco

Su(var)2-1⁰¹

suppressor of variegation | dominant, with Dp(1;Y)Bar^SCV

Su(var)2-1²¹⁰

suppressor of variegation | dominant, with In(1)sc⁸

Su(var)2-1⁰¹

suppressor of variegation | dominant, with In(1)w^m4

suppressor of variegation | dominant, with In(1)w^m4h

suppressor of variegation | dominant, with In(2LR)bw^V1

Su(var)2-1⁰¹

suppressor of variegation | dominant, with In(2LR)bw^V32g

Su(var)2-1⁰¹

suppressor of variegation | dominant, with In(2R)bw^VDe1

Su(var)2-1⁰¹

suppressor of variegation | dominant, with In(2R)bw^VDe2

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-12

Su(var)2-1⁰¹

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-42

Su(var)2-1⁰¹

suppressor of variegation | dominant, with P{hsp26-pt-T}118E-3

Su(var)2-1⁰¹

suppressor of variegation | dominant, with P{hsp26-pt-T}118E-19

Su(var)2-1⁰¹

suppressor of variegation | dominant, with P{hsp26-pt-T}118E-25-5

Su(var)2-1⁰¹

suppressor of variegation | dominant, with P{hsp26-pt-T}Abcd1^39C-34

Su(var)2-1⁰¹

suppressor of variegation | dominant, with T(1;4)w^m5

Su(var)2-1⁰¹

suppressor of variegation | dominant, with T(1;4)w^m258-18

Su(var)2-1⁰¹

suppressor of variegation | dominant, with T(1;4)w^m258-21

Su(var)2-1⁰¹

suppressor of variegation | dominant, with T(2;3)bw^VDe3

Su(var)2-1⁰¹

suppressor of variegation | dominant, with T(2;3)Sb^V

Phenotype manifest in

Allele

cystoblast

Su(var)2-1^ova-1

cystoblast, with Scer\GAL4^C587

Su(var)2-1^KK110959

cystoblast (with Su(var)2-1^ova-1)

Su(var)2-1^ova-4

cystoblast (with Su(var)2-1^ova-4)

Su(var)2-1^ova-1

egg chamber

Su(var)2-1^ds

egg chamber (with Df(2L)ED721)

female germline stem cell

Su(var)2-1^ova-1

female germline stem cell, with Scer\GAL4^C587

Su(var)2-1^KK110959

female germline stem cell (with Su(var)2-1^ova-1)

Su(var)2-1^ova-4

female germline stem cell (with Su(var)2-1^ova-4)

Su(var)2-1^ova-1

germarium

Su(var)2-1^ova-1

germarium (with Su(var)2-1^ova-1)

Su(var)2-1^ova-4

germarium (with Su(var)2-1^ova-4)

Su(var)2-1^ova-1

ovary

ovary (with Df(2L)ED721)

ovary (with Su(var)2-1^ova-1)

Su(var)2-1^ova-4

ovary (with Su(var)2-1^ova-4)

Su(var)2-1^ova-1

pigment cell

Su(var)2-1⁰¹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\NRF1

2 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Nrf1

1 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Nrf1

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\grip1

1 of 13

Yes

Xtro\LOC100485630

1 of 13

Yes

Danio rerio (Zebrafish) (1)

Drer\nrf1

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP002153

9 of 12

Yes

Agam\AgaP_AGAP002492

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Su(var)2-1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

ewg

3 of 13

MESR3

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Su(var)2-1 - HDAC1

anti tag coimmunoprecipitation, western blot

(Walther et al., 2020)

Su(var)2-1 - Scm

tandem affinity purification, Identification by mass spectrometry

(Kang et al., 2015)

Su(var)2-1 - Su(var)205

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Yang et al., 2019)

Su(var)2-1 - Su(var)3-3

two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Yang et al., 2019)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Su(var)2-1

suppressible

mod(mdg4)

(Buchner et al., 2000)

Su(var)2-1

suppressible

Su(var)205::Su(var)3-3

(Yang et al., 2019)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

E(z)

suppressible

Su(var)2-1

(Bajusz et al., 2001)

enhanceable

Su(var)208|Su(var)2-1

(Clegg et al., 1998)

enhanceable

Su(var)2-1|Su(var)208

(Clegg et al., 1998)

enhanceable

Su(var)2-1

(Clegg et al., 1998)

piwi

suppressible

Su(var)2-1

(Yang et al., 2019)

Usp47

suppressible

Su(var)2-1

(Henchoz et al., 1996)

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-40

Cytogenetic map

31B1-31B1

Sequence location

2L:10,227,760..10,231,692 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

31B1-31B1

Limits computationally determined from genome sequence between P{lacW}l(2)k06324^k06324 and P{lacW}me31B^k06607

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Location based on deficiency mapping.

(Wustmann et al., 1989)

31A2-31C1

(Wustmann et al., 1989)

Experimentally Determined Recombination Data

Location

2-40

(FlyBase, 2016)

2-34.8

(Comeron et al., 2012)

2-40.6 +/- 0.2

(Wustmann et al., 1989)

2-39.4 +/- 0.7

(Reuter et al., 1983)

2-32.0--34.2

(Sinclair et al., 1983)

2-39.5 +/- 0.7

(Reuter et al., 1982)

2-40.5

Left of (cM)

(Sinclair et al., 1992)

(Reuter et al., 1982)

Right of (cM)

Notes

2-32.0 +/- 1.4 based on Su(var)2-1²⁰⁷.

(Sinclair et al., 1983)

2-32.6 +/- 1.8 based on Su(var)2-1^210-1.

(Sinclair et al., 1983)

2-32.6 +/- 2.9 based on Su(var)2-1²¹⁴.

(Sinclair et al., 1983)

2-32.9 +/- 1.5 based on Su(var)2-1²¹⁵.

(Sinclair et al., 1983)

2-32.9 +/- 2.0 based on Su(var)2-1²¹³.

(Sinclair et al., 1983)

2-34.2 +/- 1.6 based on Su(var)2-1²¹⁶.

(Sinclair et al., 1983)

Mapping based on 3.7 x 10^-2 % recombination with 89C2-3 breakpoint of T(2;3)ap^Xa.

(Reuter et al., 1982)

Stocks and Reagents

Stocks (21)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

93160

w^* P{UASp-Flag.Su(var)2-1}1

93162

w^*; P{UASp-Flag.Su(var)2-1}attP2

62485

y¹ v¹; P{TRiP.HMJ23969}attP40/CyO

93161

w¹¹¹⁸; Su(var)2-1^ova-4 P{neoFRT}40A/CyO

77645

w¹¹¹⁸; PBac{IT.GAL4}Su(var)2-1^4027-G4/CyO

14758

y¹; P{SUPor-P}Su(var)2-1^KG08725; ry⁵⁰⁶

93158

w^*; P{UASp-λN.Su(var)2-1}attP40/CyO; P{Tub-GFP-5xBoxB}attP2

NIG-Fly

HMJ23969

y¹ v¹; P{TRiP.HMJ23969}attP40/CyO

M2L-2014

y¹ w¹¹¹⁸; Su(var)2-1^SK6 P{neoFRT}40A/CyO-Tb

M2L-2015

y¹ w¹¹¹⁸; Su(var)2-1^SK7 P{neoFRT}40A/CyO-Tb

VDRC

v102156

P{KK110959}VIE-260B

v22193

w¹¹¹⁸; P{GD11738}v22193

More stocks available...

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (59)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Walther et al., 2020)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

The Y lethal interaction with Su(var)2-1¹ depends on the amount of Y heterochromatin.

(Fanti et al., 1995)

Alleles show additive effects with mod alleles on suppression of In(1)w^m4 position effect variegation.

(Garzino et al., 1992)

The Su(var)2-1 gene is haplo-insufficient with respect to position-effect variegation.

(Sinclair et al., 1992)

Su(var) mutants have dramatic effects on chromosome morphology and gene expression but negligible effects on nuclease sensitivity of the w gene chromatin: changes due to alterations in chromosomal packaging.

(Hayashi et al., 1990)

Suppression of In(1)w^m4 position effect variegation by Su(var)2-1 was reversed by a supernumerary copy of Su(var)3-7.

(Reuter et al., 1990)

Phenotypic interactions exist between E(var) and Su(var) mutations.

(Sinclair et al., 1989)

homozygous butyrate sensitive homozygous female sterile

Su(var)2-1/+ but not Su(var)2-1/+/+ display nearly normal amounts of eye pigment in In(1)w^m4 flies. Homozygous viable; females sterile; do not produce eggs. Survival reduced by the presence of the Y chromosome or by administration of sodium n-butyrate, an inhibitor of histone deacetylation (Reuter, Dorn, and Hoffmann, 1982). Exhibits significant hyperacetylation of histone H4 and increased accessibility of chromatin to endogenous nuclease, suggesting a defect in chromosome condensation (Dorn, Heymann, Lindigkeit, and Reuter, 1986).

Relationship to Other Genes

Source for database merge of

Source for merge of: Su(var)2-1 ova

(Walther et al., 2020)

Additional comments

Five alleles defining two complementation groups.

Nomenclature History

Source for database identify of

Source for identity of: ova CG5694

(Yang et al., 2019)

Nomenclature comments

Etymology

Named 'ovaries absent' because the original mutation results in a nearly 'ovaryless' phenotype.

(Yang et al., 2019)

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

CG5694

(Liu et al., 2025, Rinehart et al., 2024, National Institute of Genetics Fly Stocks, 2022-, Walther et al., 2020, Yang et al., 2019, Caizzi et al., 2016, Clandinin and Owens, 2016-, Kang et al., 2015, Czech et al., 2013, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009)

Ova

(Vidaurre and Chen, 2021)

Su(Var)2-1

(Naumova et al., 1999)

Su(var)

(Sinclair et al., 1992)

Su(var)2

(Martin-Morris et al., 1997)

Su(var)2-1

(Walther et al., 2020, Vasanthi et al., 2013, Paredes and Maggert, 2009, Doheny et al., 2008, Le et al., 2004, Joanis and Lloyd, 2002)

Su(var)2-101

(Netter et al., 1998)

Su(var)210

(Clegg et al., 1998, Sinclair et al., 1998)

Su(var)216

(Pardue and Hennig, 1990)

Su(var)b¹⁰¹

(Reuter et al., 1983, Reuter et al., 1982)

Su-var(2)1

(Berloco et al., 2014, Szabad et al., 2012, Fanti et al., 1995, Schlossherr et al., 1994, Dorn et al., 1993, Wustmann et al., 1989)

Suvar(2)1

(Sinclair et al., 2000, Bashaw and Baker, 1996, Clegg et al., 1993, Reuter and Spierer, 1992)

Suvar(2)1^o1

ova

(Meyer-Nava et al., 2020, Yang et al., 2019)

Name Synonyms

Suppressor of variegation 2-1

ovaries absent

(Yang et al., 2019)

Secondary FlyBase IDs

FBgn0003586
FBgn0003589
FBgn0003606
FBgn0003609
FBgn0003611
FBgn0003615
FBgn0003616
FBgn0003617
FBgn0004849
FBgn0032197

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 27 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34362

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VL20

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VL20

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34362/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0290203

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0290203

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5694

MARRVEL_MODEL - MARRVEL (model organism gene)

34362

Linkouts

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0290203

References (94)

The following external sites may use different assemblies or annotations than FlyBase.

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