FlyBase Allele Report: Dmel\Su(var)2-1[ova-4]

General Information

Symbol

Dmel\Su(var)2-1^ova-4

Species

D. melanogaster

Name

FlyBase ID

FBal0346155

Feature type

allele

Associated gene

Dmel\Su(var)2-1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Yang et al., 2019)

Mutagen

CRISPR/Cas9

(Yang et al., 2019)

Progenitor genotype

Cytology

Description

Deletion of the entire coding region of ova. A 35bp fragment (gatacttgaaccagtcttttcggtatgtacctcaa) has been inserted in place of the deleted sequence.

(Yang and Xi, 2019.4.10)

Deletion of the entire coding region of ova.

(Yang et al., 2019)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

2L:10,227,409..10,230,360 [-]

Inserted_sequence:

GATACTTGAACCAGTCTTTTCGGTATGTACCTCAA

Comment:

The entire ova coding region is deleted and a 35bp fragment (gatacttgaaccagtcttttcggtatgtacctcaa) is present in its place.

(Yang and Xi, 2019.4.10)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | oogenesis (with Su(var)2-1^ova-1)

(Yang et al., 2019)

abnormal size | adult stage | female

(Yang et al., 2019)

abnormal size | adult stage | female (with Su(var)2-1^ova-1)

(Yang et al., 2019)

decreased fecundity | female

(Yang et al., 2019)

female sterile (with Su(var)2-1^ova-1)

(Yang et al., 2019)

female sterile | recessive

(Yang et al., 2019)

lethal | male limited (with Su(var)2-1^ova-1)

(Yang et al., 2019)

neoplasia | oogenesis (with Su(var)2-1^ova-1)

(Yang et al., 2019)

suppressor of variegation (with Su(var)2-1^ova-1), with P{hsp26-pt-T}39C-72

(Yang et al., 2019)

suppressor of variegation (with Su(var)2-1^ova-1), with P{hsp26-pt-T}118E-10

(Yang et al., 2019)

suppressor of variegation (with Su(var)2-1^ova-1), with P{hsp26-pt-T}Dyrk3^118E-15

(Yang et al., 2019)

suppressor of variegation (with Su(var)2-1^ova-1), with P{hsp26-pt-T}Syt7^6-M193

(Yang et al., 2019)

suppressor of variegation | dominant, with In(1)w^m4h

(Yang et al., 2019)

viable | female (with Su(var)2-1^ova-1)

(Yang et al., 2019)

Phenotype Manifest In

cystoblast (with Su(var)2-1^ova-1)

(Yang et al., 2019)

female germline stem cell (with Su(var)2-1^ova-1)

(Yang et al., 2019)

germarium (with Su(var)2-1^ova-1)

(Yang et al., 2019)

ovary

(Yang et al., 2019)

ovary (with Su(var)2-1^ova-1)

(Yang et al., 2019)

Detailed Description

Statement

Reference

ova⁴ females present rudimentary ovaries, with each oviduct only being connected to a tiny mass of cells.

The germaria of ova¹/ova⁴ transheterozygotes are either full of germline stem cell-like cells ("tumorous") or entirely germless.

(Yang et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Su(var)2-1^ova-4/Su(var)2-1^ova-1 has abnormal size | female | adult stage phenotype, suppressible | partially by Scer\GAL4^C587/Su(var)205::Su(var)3-3^UASp.cYa

(Yang et al., 2019)

Su(var)2-1^ova-4/Su(var)2-1^ova-1 has female sterile phenotype, suppressible by Scer\GAL4^C587/Su(var)205::Su(var)3-3^UASp.cYa

(Yang et al., 2019)

NOT suppressed by

Statement

Reference

Su(var)2-1^ova-4/Su(var)2-1^ova-1 has abnormal size | female | adult stage phenotype, non-suppressible by Scer\GAL4^C587/piwi^UASp.cYa

(Yang et al., 2019)

Other

Statement

Reference

Scer\GAL4^C587, Su(var)2-1^ova-4/Su(var)2-1^ova-1, Su(var)205::Su(var)3-3^UASp.cYa has female semi-sterile phenotype

(Yang et al., 2019)

Phenotype Manifest In

Suppressed by

Statement

Reference

Su(var)2-1^ova-4/Su(var)2-1^ova-1 has ovary phenotype, suppressible | partially by Scer\GAL4^C587/Su(var)205::Su(var)3-3^UASp.cYa

(Yang et al., 2019)

NOT suppressed by

Statement

Reference

Su(var)2-1^ova-4/Su(var)2-1^ova-1 has ovary phenotype, non-suppressible by Scer\GAL4^C587/piwi^UASp.cYa

(Yang et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Su(var)2-1^ova-4/Su(var)2-1^ova-1 is rescued by Su(var)2-1^+t8

(Yang et al., 2019)

Su(var)2-1^ova-4/Su(var)2-1^ova-1 is rescued by Scer\GAL4^C587/Su(var)2-1^{250-486.UASp.Tag:FLAG}

(Yang et al., 2019)

Su(var)2-1^ova-4 is rescued by Su(var)2-1^+t8

(Yang et al., 2019)

Partially rescued by

Su(var)2-1^ova-4/Su(var)2-1^ova-1 is partially rescued by Su(var)2-1^{UASp.Tag:FLAG}/Scer\GAL4^C587

(Yang et al., 2019)

Not rescued by

Su(var)2-1^ova-4/Su(var)2-1^ova-1 is not rescued by Scer\GAL4^C587/Su(var)2-1^{1-249.UASp.Tag:FLAG}

(Yang et al., 2019)

Su(var)2-1^ova-4/Su(var)2-1^ova-1 is not rescued by Su(var)2-1^{388-623.UASp.Tag:FLAG}/Scer\GAL4^C587

(Yang et al., 2019)

Su(var)2-1^ova-4/Su(var)2-1^ova-1 is not rescued by Su(var)2-1^{1-388.UASp.Tag:FLAG}/Scer\GAL4^C587

(Yang et al., 2019)

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

93161

w¹¹¹⁸; Su(var)2-1^ova-4 P{neoFRT}40A/CyO

93156

w^*; Su(var)2-1^ova-4/CyO; P{UASp-Flag.Su(var)2-1.1-388}attP2

93157

w^*; Su(var)2-1^ova-4/CyO; P{UASp-Flag.Su(var)2-1.250-486}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Su(var)2-1^ova-4

ova⁴

(Yang et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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