FlyBase Allele Report: Dmel\Su(var)2-1[ova-1]

General Information

Symbol

Dmel\Su(var)2-1^ova-1

Species

D. melanogaster

Name

FlyBase ID

FBal0346154

Feature type

allele

Associated gene

Dmel\Su(var)2-1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Yang et al., 2019)

Mutagen

ethyl methanesulfonate

(Yang et al., 2019)

Progenitor genotype

Cytology

Description

A single nucleotide deletion in a coding exon, which results in a truncated protein of 387 amino acids (aa) rather than the predicted 623 aa full length protein.

(Yang et al., 2019)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:10,228,688..10,228,688 [-]

Comment:

A single nucleotide is deleted ((A1045 of the ova CDS) leading to early translation termination after 387 amino acids.

(Yang et al., 2019)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | oogenesis (with Su(var)2-1^ova-4)

(Yang et al., 2019)

abnormal cell number | oogenesis | recessive

(Yang et al., 2019)

abnormal size | adult stage | female

(Yang et al., 2019)

abnormal size | adult stage | female (with Su(var)2-1^ova-4)

(Yang et al., 2019)

decreased fecundity | female

(Yang et al., 2019)

female sterile (with Su(var)2-1^ova-4)

(Yang et al., 2019)

lethal | male | recessive

(Yang et al., 2019)

lethal | male limited (with Su(var)2-1^ova-4)

(Yang et al., 2019)

neoplasia | oogenesis (with Su(var)2-1^ova-4)

(Yang et al., 2019)

neoplasia | oogenesis | recessive

(Yang et al., 2019)

partially lethal - majority die | female | recessive

(Yang et al., 2019)

suppressor of variegation (with Su(var)2-1^ova-4), with P{hsp26-pt-T}39C-72

(Yang et al., 2019)

suppressor of variegation (with Su(var)2-1^ova-4), with P{hsp26-pt-T}118E-10

(Yang et al., 2019)

suppressor of variegation (with Su(var)2-1^ova-4), with P{hsp26-pt-T}Dyrk3^118E-15

(Yang et al., 2019)

suppressor of variegation (with Su(var)2-1^ova-4), with P{hsp26-pt-T}Syt7^6-M193

(Yang et al., 2019)

viable | female (with Su(var)2-1^ova-4)

(Yang et al., 2019)

Phenotype Manifest In

cystoblast

(Yang et al., 2019)

cystoblast (with Su(var)2-1^ova-4)

(Yang et al., 2019)

female germline stem cell

(Yang et al., 2019)

female germline stem cell (with Su(var)2-1^ova-4)

(Yang et al., 2019)

germarium

(Yang et al., 2019)

germarium (with Su(var)2-1^ova-4)

(Yang et al., 2019)

ovary

(Yang et al., 2019)

ovary (with Su(var)2-1^ova-4)

(Yang et al., 2019)

Detailed Description

Statement

Reference

ova¹ and ova¹/ova⁴ females present rudimentary ovaries. In agreement, ova¹ females do not lay any eggs but do not show any other notable defects

ova¹ female germline clones behave normally: the mutant clones are maintained in the niche, their descendant cells properly differentiate into germline cysts and the resulting egg chambers properly specify the oocyte.

The germaria of both ova¹ homozygotes and ova¹/ova⁴ transheterozygotes are either full of germline stem cell-like cells ("tumorous") or entirely germless.

(Yang et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Su(var)2-1^ova-4/Su(var)2-1^ova-1 has abnormal size | female | adult stage phenotype, suppressible | partially by Scer\GAL4^C587/Su(var)205::Su(var)3-3^UASp.cYa

(Yang et al., 2019)

Su(var)2-1^ova-4/Su(var)2-1^ova-1 has female sterile phenotype, suppressible by Scer\GAL4^C587/Su(var)205::Su(var)3-3^UASp.cYa