FlyBase Allele Report: Dmel\Su(var)2-1[01]

General Information

Symbol

Dmel\Su(var)2-1⁰¹

Species

D. melanogaster

Name

FlyBase ID

FBal0407380

Feature type

allele

Associated gene

Dmel\Su(var)2-1

Associated Insertion(s)

Carried in Construct

Also Known As

Su-var(2)1⁰¹, Suvar(2)1⁰¹

Key Links

Allele class

antimorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Sinclair et al., 1992)

Mutagen

spontaneous

(Sinclair et al., 1992, Reuter et al., 1983, Reuter et al., 1982)

Progenitor genotype

Cytology

Description

Frameshift or stop mutation starting at codon 349.

(Walther et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Reuter et al., 1983)

lethal | male | recessive

(Reuter et al., 1982)

lethal | recessive

(Sinclair et al., 1992)

majority die during embryonic stage

(Berloco et al., 2014)

non-suppressor of variegation | dominant, with P{hsp26-pt-T}118E-10

(Sun et al., 2000)

partially lethal | female

(Reuter et al., 1982)

partially lethal - majority die

(Berloco et al., 2014)

partially lethal - majority die (with Df(YL)S6)

(Berloco et al., 2014)

partially lethal - majority die (with Df(YS)S12)

(Berloco et al., 2014)

partially lethal - majority live (with Df(YL)S10)

(Berloco et al., 2014)

suppressor of variegation, with In(1)w^m4h

(Buchner et al., 2000, Laible et al., 1997)

suppressor of variegation | dominant

(Reuter et al., 1983)

suppressor of variegation | dominant, with Dp(1;3)w^vco

(Reuter et al., 1982)

suppressor of variegation | dominant, with In(1)sc⁸

(Reuter et al., 1982)

suppressor of variegation | dominant, with In(1)w^m4

(Sinclair et al., 1992)

suppressor of variegation | dominant, with In(1)w^m4h

(Westphal and Reuter, 2002, Dorn et al., 1993, Reuter et al., 1982)

suppressor of variegation | dominant, with In(2LR)bw^V1

(Reuter et al., 1982)

suppressor of variegation | dominant, with In(2LR)bw^V32g

(Reuter et al., 1982)

suppressor of variegation | dominant, with In(2R)bw^VDe1

(Reuter et al., 1982)

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-12

(Sun et al., 2000)

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-42

(Sun et al., 2000)

suppressor of variegation | dominant, with P{hsp26-pt-T}118E-3

(Sun et al., 2000)

suppressor of variegation | dominant, with P{hsp26-pt-T}118E-19

(Sun et al., 2000)

suppressor of variegation | dominant, with P{hsp26-pt-T}118E-25-5

(Sun et al., 2000)

suppressor of variegation | dominant, with P{hsp26-pt-T}Abcd1^39C-34

(Sun et al., 2000)

suppressor of variegation | dominant, with T(1;4)w^m5

(Reuter et al., 1982)

suppressor of variegation | dominant, with T(1;4)w^m258-18

(Reuter et al., 1982)

suppressor of variegation | dominant, with T(1;4)w^m258-21

(Reuter et al., 1982)

suppressor of variegation | dominant, with T(2;3)bw^VDe3

(Reuter et al., 1982)

Phenotype Manifest In

pigment cell

(Buchner et al., 2000)

Detailed Description

Statement

Reference

X/Y males homozygous for Su(var)2-1¹ are almost completely lethal, whereas homozygous X/0 males are almost completely viable. The lethality is mainly concentrated at the embryo stage. The lethal interaction between Su(var)2-1¹ and Y is correlated with size of the Y chromosome fragments, as tested with Df(YL)S10, Df(YS)S12, and Df(YL)S6.

(Berloco et al., 2014)

Heterozygotes show no effect on crossing over between kni and p^p.

(Westphal and Reuter, 2002)

In X/O males carnitine compounds have a lethal interaction.

(Fanti et al., 1994)

mod(mdg4)^neo129 suppresses the strong dominant suppressor effect.

(Dorn et al., 1993)

Suppresses In(1)w^m4 and T(2;3)Sb^V and enhances the variegation phenotype of In(2R)bw^VDe2. Homozygous embryos are semi-viable. The effect of the Su(var)2-1¹ allele is slightly reduced in heterozygotes with Df(2R)M41A10 (which lacks 2R heterochromatin). The extent of hemizygous lethality is dramatically enhanced in the presence of extra heterochromatin (attachedXX/Y females) whereas the lethality did not occur in the absence of the Y (X/O males).

(Sinclair et al., 1992)

Dominant suppressor effect for position-effect variegation. Homozygous lethal and semi-sterile in males.

(Reuter et al., 1983)

Semilethal in females. Dominant suppressor of w variegation caused by In(1)w^m4h, T(1;4)w^m5, T(1;4)w^m258-18, Dp(1;3)w^vco and T(1;4)w^m258-21. Significantly decreases heterochromatinisation in flies carrying T(1;4)w^m258-21. Dominant suppressor of bw variegation caused by In(2LR)bw^V32g, In(2R)bw^VDe1, In(2LR)bw^V1 and T(2;3)bw^VDe3. Dominant suppressor of bb variegation caused by Dp(1;3)w^vco and sc variegation caused by In(1)sc⁸.

(Reuter et al., 1982)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

In(1)w^m4h, Su(var)2-1⁰¹ has suppressor of variegation phenotype, suppressible by mod(mdg4)^neo129/mod(mdg4)[+]

(Buchner et al., 2000)

In(1)w^m4h, Su(var)2-1⁰¹ has suppressor of variegation phenotype, suppressible by mod(mdg4)[+]/mod(mdg4)^R32

(Buchner et al., 2000)

In(1)w^m4h, Su(var)2-1⁰¹ has suppressor of variegation phenotype, suppressible by mod(mdg4)⁰³/mod(mdg4)[+]

(Buchner et al., 2000)

In(1)w^m4h, Su(var)2-1⁰¹ has suppressor of variegation phenotype, suppressible by mod(mdg4)⁰⁴/mod(mdg4)[+]

(Buchner et al., 2000)

In(1)w^m4h, Su(var)2-1⁰¹ has suppressor of variegation phenotype, suppressible by mod(mdg4)[+]/mod(mdg4)⁰⁵

(Buchner et al., 2000)

In(1)w^m4h, Su(var)2-1⁰¹ has suppressor of variegation phenotype, suppressible by mod(mdg4)⁰⁶/mod(mdg4)[+]

(Buchner et al., 2000)

In(1)w^m4h, Su(var)2-1⁰¹ has suppressor of variegation phenotype, suppressible by mod(mdg4)⁰⁷/mod(mdg4)[+]

(Buchner et al., 2000)

In(1)w^m4h, Su(var)2-1⁰¹ has suppressor of variegation phenotype, suppressible by mod(mdg4)^142Δ32/mod(mdg4)[+]

(Buchner et al., 2000)

Enhancer of

Statement

Reference

Su(var)2-1⁰¹ is an enhancer of abnormal eye color phenotype of lt¹/lt¹¹

(Clegg et al., 1998)

Su(var)2-1[+], Su(var)208[+], Su(var)208¹, Su(var)2-1⁰¹ is an enhancer of abnormal eye color phenotype of lt¹/lt¹¹

(Clegg et al., 1998)

Su(var)208¹/Su(var)2-1⁰¹ is an enhancer of abnormal eye color | recessive phenotype of lt¹¹

(Clegg et al., 1998)

Other

Statement

Reference

Su(var)2-1⁰¹, Su(var)205^unspecified, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)2-1⁰¹, Su(var)208¹, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁶/Su(var)2-1⁰¹, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

Su(var)2-1⁰¹, rl^unspecified has visible phenotype

(Sinclair et al., 2000)

E(lt^v)319³¹⁹, Su(var)2-1⁰¹, lt¹¹ has viable phenotype

(Clegg et al., 1998)

E(lt^v)319³¹⁹, Su(var)2-1⁰¹, lt¹¹ has abnormal eye color phenotype

(Clegg et al., 1998)

Su(var)2-1^v9/Su(var)2-1⁰¹, lt¹ has partially lethal | recessive | male phenotype

(Clegg et al., 1998)

Su(var)2-1^v9/Su(var)2-1⁰¹, lt¹¹ has partially lethal | recessive | male phenotype

(Clegg et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

Su(var)2-1⁰¹ is an enhancer of pigment cell phenotype of lt¹/lt¹¹

(Clegg et al., 1998)

Su(var)2-1[+], Su(var)208[+], Su(var)208¹, Su(var)2-1⁰¹ is an enhancer of pigment cell phenotype of lt¹/lt¹¹

(Clegg et al., 1998)

Su(var)208¹/Su(var)2-1⁰¹ is an enhancer of pigment cell phenotype of lt¹¹

(Clegg et al., 1998)

Suppressor of

Statement

Reference

Su(var)2-1⁰¹ is a suppressor of adult mesothoracic segment | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

Su(var)2-1⁰¹ is a suppressor of adult metathoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

Su(var)2-1⁰¹ is a suppressor of adult prothoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

Su(var)2-1⁰¹ is a suppressor of phenotype of Usp47^Evar1

(Henchoz et al., 1996)

Other

Statement

Reference

In(1)w^m4h, Su(var)2-1⁰¹, mod(mdg4)⁰⁷/mod(mdg4)[+] has pigment cell phenotype

(Buchner et al., 2000)

In(1)w^m4h, Su(var)2-1⁰¹, mod(mdg4)^142Δ32/mod(mdg4)[+] has pigment cell phenotype

(Buchner et al., 2000)

In(1)w^m4h, Su(var)2-1⁰¹, mod(mdg4)^neo129/mod(mdg4)[+] has pigment cell phenotype

(Buchner et al., 2000)

In(1)w^m4h, Su(var)2-1⁰¹, mod(mdg4)[+]/mod(mdg4)^R32 has pigment cell phenotype

(Buchner et al., 2000)

In(1)w^m4h, Su(var)2-1⁰¹, mod(mdg4)⁰³/mod(mdg4)[+] has pigment cell phenotype

(Buchner et al., 2000)

In(1)w^m4h, Su(var)2-1⁰¹, mod(mdg4)⁰⁴/mod(mdg4)[+] has pigment cell phenotype

(Buchner et al., 2000)

In(1)w^m4h, Su(var)2-1⁰¹, mod(mdg4)[+]/mod(mdg4)⁰⁵ has pigment cell phenotype

(Buchner et al., 2000)

In(1)w^m4h, Su(var)2-1⁰¹, mod(mdg4)⁰⁶/mod(mdg4)[+] has pigment cell phenotype

(Buchner et al., 2000)

Su(var)2-1⁰¹, Su(var)205^unspecified, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)2-1⁰¹, Su(var)208¹, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)2-1²¹⁶/Su(var)2-1⁰¹, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

Su(var)2-1⁰¹, rl^unspecified has eye phenotype

(Sinclair et al., 2000)

E(lt^v)319³¹⁹, Su(var)2-1⁰¹, lt¹¹ has pigment cell phenotype

(Clegg et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Su(var)205^unspecified shows semi-lethality with Su(var)2-1¹ in females with a Y chromosome.

(Sinclair et al., 2000)

Eye pigmentation in lt¹¹/lt¹ flies is reduced if the flies are also carrying Su(var)208^unspecified/Su(var)2-1¹ or Su(var)2-1^v9/Su(var)2-1¹. XY lt¹¹/lt¹; Su(var)2-1^v9/Su(var)2-1¹ males have reduced viability, which is restored in XO males. Eye pigmentation is reduced and viability is essentially wild-type in lt¹¹/+ flies that are also carrying or Su(var)2-1^v9 and E(lt^v)319³¹⁹.

(Clegg et al., 1998)

The effect of loss of one copy of Su(var)2-1¹ can be rescued by P-element mediated transformation with Su(var)3-7.

(Reuter et al., 1990)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

non-complementing

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

6232

In(1)w^m4h; Su(var)2-1⁰¹/In(2L)Cy^Lt^R, In(2R)Cy, Duox^Cy amos^Roi-1 pr¹ cn¹

6265

In(1)w^m4h; Su(var)2-1⁰¹ sna^Sco/In(2L)Cy^Lt^R, In(2R)Cy, Duox^Cy amos^Roi-1 pr¹ cn¹; ry⁵⁰⁶

Kyoto

103360

In(1)w^m4h ; Su(var)2-1⁰¹ sna^Sco / In(2L)t In(2R)Cy, Duox^Cy amos^Roi-1 pr¹ cn¹ ; ry⁵⁰⁶

Notes on Origin

Discoverer

Comments

Used as the genetic background in a screen to identify enhancers of PEV.

(Dorn et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

2-1⁰¹

(Walther et al., 2020)

S-var(2)1⁰¹

(Weiler and Wakimoto, 1995, Fanti et al., 1994)

Su(var)2-101

(Netter et al., 1998)

Su(var)2-1⁰¹

(Vasanthi et al., 2013, Paredes and Maggert, 2009, Boivin et al., 2003, Erhardt et al., 2003, Westphal and Reuter, 2002, Hwang et al., 2001, Zhao et al., 2001, Buchner et al., 2000, Gvozdev et al., 2000, Naumova et al., 2000, Sun et al., 2000, Laible et al., 1997, Henchoz et al., 1996)

Su(var)2-1¹⁰¹

Su(var)2-1¹

(Dorn et al., 1993)

Su(var)2⁰¹

(Martin-Morris et al., 1997)

Su(var)b¹⁰¹

(Reuter et al., 1982)

Su-var(2)101

(Fauvarque and Dura, 1993)

Su-var(2)1⁰¹

(Berloco et al., 2014, Elgin, 1996, Fanti et al., 1995, Schlossherr et al., 1994, Dorn et al., 1993, Reuter et al., 1982)

Suvar(2)1⁰¹

(Sinclair et al., 2000, Clegg et al., 1998, Reuter and Spierer, 1992, Sinclair et al., 1992, Reuter et al., 1990)

Name Synonyms

Secondary FlyBase IDs

FBal0016489
FBal0030276
FBal0058203

References (37)

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