FlyBase Allele Report: Dmel\lt[1]

General Information

Symbol

Dmel\lt¹

Species

D. melanogaster

Name

FlyBase ID

FBal0011677

Feature type

allele

Associated gene

Dmel\lt

Associated Insertion(s)

Carried in Construct

Also Known As

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Weiler and Wakimoto, 1998, Howe et al., 1995, Hearn et al., 1991, Tearle, 1991, Wakimoto and Hearn, 1990)

Mutagen

spontaneous

(Weiler and Wakimoto, 1998)

Progenitor genotype

Cytology

Description

Deletion of approximately 200bp.

(Devlin et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Weiler and Wakimoto, 1998)

abnormal eye color | recessive

(Clegg et al., 1998, Warner et al., 1998)

short lived | male

(Simonsen et al., 2007)

suppressor of variegation (with In(2L)lt^X2), with E(var)3-9³

(Weiler, 2007)

suppressor of variegation | dominant (with In(2L)lt^X2), with E(var)3-9¹

(Weiler, 2007)

suppressor of variegation | dominant (with In(2L)lt^X2), with E(var)3-9²

(Weiler, 2007)

viable

(Warner et al., 1998, Howe et al., 1995)

Phenotype Manifest In

Malpighian tubule

(Devlin et al., 1990, Nickla, 1972)

ocellus pigment granule

pigment cell

(Clegg et al., 1998, Warner et al., 1998, Weiler and Wakimoto, 1998)

Detailed Description

Statement

Reference

lt¹ mutant third instar larvae do not show accumulations of acidic organelles (marked by Lysotracker) in the somatic muscles.

(Bharadwaj et al., 2016)

Mutant males have a shortened adult life span compared to controls, with a mean life span of 24.92 days at 25^o.

(Simonsen et al., 2007)

Eye colour: uniform orange.

(Weiler and Wakimoto, 1998)

Disrupt ommochrome and pteridine synthesis.

(Tearle, 1991)

Eye colour: orange, with lt^hdS1. Malpighian tubule colour: reduced. Homozygous larvae have a low level of pigmentation in the Malpighian tubules, with a uniform distribution of small pigment granules.

(Devlin et al., 1990)

The amount of such pigment in Malpighian tubules increases with maternal age for both lt¹/+ and lt¹/lt¹ parental females.

(Nickla, 1973)

Drosopterins drastically reduced; no maternal effect in homozygous germ-line clones on eye pigmentation.

(Nickla, 1972)

Malpighian tubule colour: colourless in lt¹ offspring of lt¹ mothers. Malpighian tubule colour: some colour in lt¹ offspring of lt¹/+ mothers. The quantity of yellow pigment, composed primarily of riboflavin, in Malpighian tubes exhibits parallel maternal effects in larvae, pupae and adults.

(Nickla, 1972)

Eye color autonomous in mutant optic discs transplanted into wild-type hosts.

(Beadle and Ephrussi, 1936)

Eye colour: slightly lighter than lt¹ alone, with st¹. Eye colour: clear yellow, pinkish in old flies, with bw¹.

(Schultz and Dobzhansky, 1934)

Eye colour: yellowish pink; lighter at high temperature, darker at low. Ocellus colour: colourless.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

lt¹/lt¹¹ has abnormal eye color phenotype, enhanceable by Su(var)2-1⁰¹

(Clegg et al., 1998)

lt¹/lt¹¹ has abnormal eye color phenotype, enhanceable by Su(var)2-1[+]/Su(var)208[+]/Su(var)208¹/Su(var)2-1⁰¹

(Clegg et al., 1998)

lt¹/lt¹¹ has abnormal eye color phenotype, enhanceable by Su(var)2-1[+]/Su(var)208[+]/Su(var)208¹/Su(var)2-1^v9

(Clegg et al., 1998)

lt¹/lt¹¹ has abnormal eye color phenotype, enhanceable by Su(var)2-1^v9

(Clegg et al., 1998)

lt¹/lt¹¹ has abnormal eye color phenotype, enhanceable by Su(var)205[+]/E(Pc)[+]/Su(var)205¹/E(Pc)^unspecified

(Clegg et al., 1998)

lt¹/lt¹¹ has abnormal eye color phenotype, enhanceable by Su(var)208[+]/Su(var)208¹/E(Pc)[+]/E(Pc)^unspecified

(Clegg et al., 1998)

lt¹/lt¹¹ has abnormal eye color phenotype, enhanceable by Su(var)208[+]/Su(var)208¹/Su(var)205[+]/Su(var)205¹

(Clegg et al., 1998)

Other

Statement

Reference

Su(var)2-1^v9/Su(var)2-1⁰¹, lt¹ has partially lethal | recessive | male phenotype

(Clegg et al., 1998)

Su(var)2-1^v9, Su(var)205¹, lt¹/lt¹¹ has partially lethal phenotype

(Clegg et al., 1998)

Su(var)205¹, Su(var)208¹, lt¹/lt¹¹ has partially lethal phenotype

(Clegg et al., 1998)

car¹, lt¹ has lethal | recessive phenotype

(Warner et al., 1998, Nickla, 1977)

car¹, lt¹/lt¹¹ has lethal phenotype

(Warner et al., 1998)

dor¹, lt¹/lt¹¹ has lethal phenotype

(Warner et al., 1998)

car¹, lt¹/lt¹¹ has lethal | recessive phenotype

(Warner et al., 1998)

dor¹, lt¹/lt¹¹ has lethal | recessive phenotype

(Warner et al., 1998)

dor¹, lt¹ has lethal | recessive phenotype

(Warner et al., 1998)

g^53d, lt¹ has abnormal eye color | recessive phenotype

(Warner et al., 1998)

g^53d, lt¹/lt¹¹ has abnormal eye color | recessive phenotype

(Warner et al., 1998)

lt¹, stw¹ has lethal | recessive phenotype

(Lindsley and Grell, 1968)

lt¹, stw³ has viable phenotype

(Lindsley and Grell, 1968)

Phenotype Manifest In

Enhanced by

Statement

Reference

lt¹/lt¹¹ has pigment cell phenotype, enhanceable by Su(var)2-1⁰¹

(Clegg et al., 1998)

lt¹/lt¹¹ has pigment cell phenotype, enhanceable by Su(var)2-1[+]/Su(var)208[+]/Su(var)208¹/Su(var)2-1⁰¹

(Clegg et al., 1998)

lt¹/lt¹¹ has pigment cell phenotype, enhanceable by Su(var)2-1[+]/Su(var)208[+]/Su(var)208¹/Su(var)2-1^v9

(Clegg et al., 1998)

lt¹/lt¹¹ has pigment cell phenotype, enhanceable by Su(var)2-1^v9

(Clegg et al., 1998)

lt¹/lt¹¹ has pigment cell phenotype, enhanceable by Su(var)205[+]/E(Pc)[+]/Su(var)205¹/E(Pc)^unspecified

(Clegg et al., 1998)

lt¹/lt¹¹ has pigment cell phenotype, enhanceable by Su(var)208[+]/Su(var)208¹/E(Pc)[+]/E(Pc)^unspecified

(Clegg et al., 1998)

lt¹/lt¹¹ has pigment cell phenotype, enhanceable by Su(var)208[+]/Su(var)208¹/Su(var)205[+]/Su(var)205¹

(Clegg et al., 1998)

NOT suppressed by

Statement

Reference

lt¹ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Other

Statement

Reference

g^53d, lt¹ has pigment cell phenotype

(Warner et al., 1998)

g^53d, lt¹/lt¹¹ has pigment cell phenotype

(Warner et al., 1998)

car¹, lt¹ has larval brain phenotype

(McCarthy and Nickla, 1980)

car¹, lt¹ has ventral nerve cord phenotype

(Nickla et al., 1980)

Additional Comments

Genetic Interactions

Statement

Reference

The variegation of lt seen in lt¹/T(2;3)lt^X13 flies is enhanced by Df(3R)Ace-HD1.

(Delattre et al., 2000)

Eye pigmentation in lt¹¹/lt¹ flies is reduced if the flies are also carrying E(Pc)^unspecified/Su(var)205¹, E(Pc)^unspecified/Su(var)208^unspecified, Su(var)208^unspecified/Su(var)205¹, Su(var)208^unspecified/Su(var)2-1¹, Su(var)2-1^v9/Su(var)2-1¹ or Su(var)2-1^v9/Su(var)208^unspecified. XY lt¹¹/lt¹; Su(var)2-1^v9/Su(var)2-1¹ males have reduced viability, which is restored in XO males. lt¹¹/lt¹; Su(var)2-1^v9/Su(var)205¹ flies have reduced viability. Viability is partially restored in XO males. lt¹¹/lt¹; Su(var)208^unspecified/Su(var)205¹ flies have reduced viability. Viability is restored in XO males.

(Clegg et al., 1998)

Eye colour: lt¹ g^53d double mutants show a marked reduction in eye pigment. Eye colour: lt¹/lt¹¹ g^53d double mutants show a reduction in red eye pigment compared to either lt¹/lt¹¹ or g^53d single mutants.

(Warner et al., 1998)

Lethal focus of the lt car lethal interaction as measured in car¹/+; lt¹/lt¹, car¹/0; lt¹/lt¹ gynandromorphs is in ventral nervous tissue.

(Nickla et al., 1980)

The time of death of lt¹ car¹ double homozygotes varies from the third larval instar to late pupa, depending on the number of normal alleles of either gene carried by the mother.

(Nickla, 1977)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

lt^56c

(Meyer, 1956)

Comments

Images (2)

Holtzman, S. and Kaufman, T. (2013)

Mutant