Frameshift or stop mutation starting at codon 279.
One copy of Su(var)2-1214 strongly suppresses position effect variegation (PEV) at the w locus caused by In(1)wm4.
One copy of Su(var)2-1214 is unable to suppress the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.
Homozygous embryos are semi-viable. Moderate to strong maternal effects as seen by elevated w+ eye pigment levels in non-suppressor bearing offspring of Su(var) females. Removal of segments of heterochromatin from the genome by loss of the Y chromosome abolishes the suppression of the position effect variegation phenotype. The effect of the Su(var)2-1214 allele is reduced in heterozygotes with Df(2R)M41A10 (which lacks 2R heterochromatin).
Does not enhance variegation at the lt locus.
Dominant suppressor of position effect variegation in eye pigment caused by In(1)wm4 or In(2R)bwVDe2. Dominant suppressor of position effect variegation at the Sb locus caused by T(2;3)SbV. The suppressor effect on the variegation caused by In(1)wm4 is substantially reduced or eliminated entirely in male XO flies lacking a Y chromosome.
Su(var)2-1214, rlunspecified has visible phenotype
Su(var)2-1214, Su(var)205unspecified, rlunspecified has visible phenotype
Su(var)2-1214, Su(var)2081, rlunspecified has visible phenotype
Su(var)2-1214, rlunspecified has eye phenotype
Su(var)2-1214, Su(var)205unspecified, rlunspecified has eye phenotype
Su(var)2-1214, Su(var)2081, rlunspecified has eye phenotype
Su(var)205unspecified shows semi-lethality with Su(var)2-1214 in females with a Y chromosome.
Originally isolated as a dominant suppressor of the w+ gene on In(1)wm4.