FB2026_02 , released June 18, 2026
Allele: Dmel\SxlM1,fPa-ra
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General Information
Symbol
Dmel\SxlM1,fPa-ra
Species
D. melanogaster
Name
FlyBase ID
FBal0016706
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Temperature-dependent transformation from male to female external cuticle phenotype. Expression of trahs.PB female specific product in SxlM1,fPa-ra individuals causes the external sexually dimorphic cuticle of male flies to develop with a female morphology, the muscle phenotype remained male-like.

Hemizygous males are viable at 22oC or 25oC. When in trans with a copy of Sxl+ viability is dramatically reduced at 25oC and the same at 22oC.

This complex allele disrupts both male and female development, with the magnitude of the effects in either sex depending on culture temperature in a reciprocal fashion: high temperature is more permissive for females and less permissive (more feminizing) for males. Intersexual males show little male sexual behavior and stimulate courtship from other males. Dominant male-lethal effects are greatly enhanced by the presence of a duplication of Sxl+ in trans; male escapers with both alleles exhibit an unusual dorsalization of the abdomen, their sternites being variably transformed into tergites. complex partial revertant of SxlM1,fPa complementing Sxlf9; male ts; female cs

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: Having regained the ability to complement Sxlf9. Revertant. \partial

Comments
Comments

Express constitutively low levels of Sxl function.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
SxlM1,fPa-ra
SxlM1fPa-ra
Name Synonyms
Secondary FlyBase IDs
    References (6)