FlyBase Allele Report: Dmel\t[5]

General Information

Symbol

Dmel\t⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0016718

Feature type

allele

Associated gene

Dmel\t

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: M256I.

(True et al., 2005)

Dopamine level less than t⁺.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:9,218,689..9,218,689 [-]

Nucleotide change:

G9218689H

Amino acid change:

M256I | t-PA; M256I | t-PB

Reported amino acid change:

M256I

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(True et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color

(Wittkopp et al., 2009, Jeong et al., 2008, True et al., 2005)

visible | recessive

Phenotype Manifest In

adult cuticle

(Wittkopp et al., 2009, Jeong et al., 2008)

Detailed Description

Statement

Reference

Body colour: mutant males lack black melanin in the cuticle and the striped and male-specific abdominal pigmentation is strongly reduced.

(Jeong et al., 2008)

Body color: tan.

(True et al., 2005)

Dopamine, an important component of catecholamine metabolism (involved in both melanization of cuticle and synthesis of neurotransmitters), has been found in reduced amounts (about 60% of the wild-type concentration) in t¹ and t⁵.

(Konopka, 1972)

ERG abnormal.

(Benzer, 1967)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

t⁵ has abnormal body color phenotype, suppressible by Dnov\tan^tWa

(Wittkopp et al., 2009)

t⁵ has abnormal body color phenotype, suppressible by Dame\tan^tWa

(Wittkopp et al., 2009)

Phenotype Manifest In

Suppressed by

Statement

Reference

t⁵ has adult cuticle phenotype, suppressible by Dnov\tan^tWa

(Wittkopp et al., 2009)

t⁵ has adult cuticle phenotype, suppressible by Dame\tan^tWa

(Wittkopp et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Body colour: in y^unspecified t⁵ double mutant males, the spatial pattern of abdominal pigmentation appears similar to that of the t⁵ single mutant, while the intensity of pigmentation resembles that of the y^unspecified single mutant.

(Jeong et al., 2008)

Xenogenetic Interactions

Statement

Reference

Pigmentation is rescued in D. melanogaster t⁵ flies if they are carrying either Dnov\tan^tWa or Dame\tan^tWa, with flies carrying the Dame\tan^tWa allele having darker pigmentation than those carrying the Dnov\tan^tWa allele.

(Wittkopp et al., 2009)

Complementation and Rescue Data

Fails to complement

t^d07784

(True et al., 2005)

t¹

(Benzer, 1967)

Rescued by

t⁵ is rescued by t^+t10.3

(Jeong et al., 2008)

t⁵ is rescued by Scer\GAL4^C-765/t^UAS.cTa

(True et al., 2005)