FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tl6
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General Information
Symbol
Dmel\Tl6
Species
D. melanogaster
Name
FlyBase ID
FBal0016831
Feature type
allele
Associated gene
Dmel\Tl
Associated Insertion(s)
Carried in Construct
Also Known As
Tl2b
Key Links
Genomic Maps

Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Schneider et al., 1991)
Mutagen
ethyl methanesulfonate
(Lindsley and Zimm, 1992, Erdelyi and Szabad, 1989)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q614term.

(Schneider et al., 1991)

Mutation in the extracellular domain of the protein.

(Schneider et al., 1991)

Nucleotide substitution: C2414T.

(Schneider et al., 1991)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:26,839,693..26,839,693 [+]
Nucleotide change:

C26839693T

Reported nucleotide change:

C2414T

Amino acid change:

Q614term | Tl-PB; Q614term | Tl-PC; Q614term | Tl-PD

Reported amino acid change:

Q614term

Comment:

This mutation is in the extracellular domain of the protein.

(Schneider et al., 1991)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Semidominant.

      (Lindsley and Zimm, 1992)

      Embryos from heterozygous females are weakly ventralised at 29oC, and moderately ventralised at 18oC. Females carrying Tl6 in trans with a null allele of Tl produce dorsalised embryos.

      (Schneider et al., 1991)

      Female viability and male fertility are not reduced. Embryos exhibit ventralised phenotype.

      (Erdelyi and Szabad, 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Class II allele.

      (Schneider et al., 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Tl2b
      (Lindsley and Zimm, 1992, Schneider et al., 1991, Erdelyi and Szabad, 1989)
      Tl6
      Name Synonyms
      Secondary FlyBase IDs
        References (3)