FB2025_05 , released December 11, 2025
Allele: Dmel\tllle3
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General Information
Symbol
Dmel\tllle3
Species
D. melanogaster
Name
FlyBase ID
FBal0016894
Feature type
allele
Associated gene
Dmel\tll
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Diaz et al., 1996)
Progenitor genotype
Cytology
Description

Amino acid replacement: G43S. Nucleotide substitution: GGC to AGC. Residue is near the tip of the first zinc finger.

(Diaz et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:30,852,794..30,852,794 [+]
Nucleotide change:

G30852794A

Reported nucleotide change:

G480A

Amino acid change:

G43S | tll-PA

Reported amino acid change:

G43S

(Diaz et al., 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous tllle3 mutant flies do not show an increase in aggressive behavior compared to controls. No obvious anatomical defects are seen in the brains of these flies.

      (Davis et al., 2014)

      Embryos exhibit reduced or missing anal pads but the hindgut is almost normal in size.

      (Diaz et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Severity of the embryonic phenotype (deletion of either external structures, A8 or anal pads, or internal structures, hindgut) places tll alleles in the order: Df(3R)tll-pgx > tlll49 > tll1 > tlll29 > tll2 > tllle3.

      (Diaz et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tlllE3
      (Davis et al., 2014)
      tllle3
      Name Synonyms
      Secondary FlyBase IDs
        References (3)