FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\twr2
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General Information
Symbol
Dmel\twr2
Species
D. melanogaster
Name
FlyBase ID
FBal0017308
Feature type
allele
Associated gene
Dmel\twr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lewis et al., 1980)
Progenitor genotype
Cytology
Description

G to A mutation at coordinate 3R:2484724 (release 5). The mutation disrupts the splice acceptor site of exon 3.

(Wang et al., 2010)

Nucleotide substitution: G?A.

(Wang et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:6,659,002..6,659,002 [+]
Nucleotide change:

G6659002A

Reported nucleotide change:

G2484724A

Comment:

G to A mutation in the splice acceptor for inron 2.

(Wang et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      twr1/twr2 flies have a rough eye phenotype with disorganisation of the ommatidia and degenerative photoreceptors.

      (Wang et al., 2010)

      Lethal when heterozygous with Df(3R)Scr.

      (Lewis et al., 1980)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Wakimoto.

      (Lindsley and Zimm, 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      EfW9
      (Lewis et al., 1980)
      twr2
      (Wang et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)