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General Information
Symbol
Dmel\Ubxpbx-2
Species
D. melanogaster
Name
FlyBase ID
FBal0017569
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
pbx2
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Caused by aberration
Cytology
Nature of the lesion
Statement
Reference

The deletion that causes this allele also deletes regions of the neighbouring bxd non-coding RNA gene.

Cis-regulatory mutation.

Deletion of DNA in the distal part of the bxd regulatory region.

Deletion at Ubx at -30kb with respect to transcription start site.

Deletion of DNA within the pbx regulatory region.

Deletion of Ubx sequences.

Deletion of DNA.

Deletion of 15kb from map position -14 to +1kb.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

A few double heterozygotes for ash128 at 27oC exhibit haltere to wing transformation. Double heterozygotes for ash218 at 20oC exhibit very mild haltere to wing transformation and at 27oC exhibit very mild third to second leg transformation.

Homozygotes show complete T3p to T2p ("pbx") transformation. A1a is not affected.

Increases the frequency of the trx bithorax-variegated phenotype in heterozygous combination with Df(3R)red-P52.

The Ubxpbx-2 is almost completely complemented when heterozygous with pseudopoint or point mutations of Ubx. In the presence of a transvection suppressing chromosome rearrangement (TSR) there is a strong transformation of T3p to T2p.

Hemizygous flies show transformation of posterior haltere to wing and have extra dorsal postnotal tissue. These flies show variable slight reduction of the first abdominal tergite.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Ubx mutants have been classified into "transvection groups", on the basis of transvection tests with Ubxbx-34e, Ubxpbx-2, and UbxCbx-1 Ubx1 mutants. Ubxpbx-2 is transvection positive with Ubx point, pseudopoint and most breakpoint alleles. The Tp(3;3)bxd100 breakpoint marks the distal limit for transvection positive rearrangements.

The phenotype of a number of combinations of Ubx mutations has been investigated to determine the role of the bxd regulatory region in the modulation of Ubx expression.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (16)