FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\upwhu
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General Information
Symbol
Dmel\upwhu
Species
D. melanogaster
Name
FlyBase ID
FBal0017632
Feature type
allele
Associated gene
Dmel\up
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Amino acid replacement: S311F. Nucleotide substitution: C?T.

(Fyrberg et al., 1990)

Ser311>Phe311 TCC>TTC

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:13,594,050..13,594,050 [-]
Nucleotide change:

C13594050T

Reported nucleotide change:

TCC?TTC

Amino acid change:

S313F | up-PA; S305F | up-PB; S222F | up-PD; S290F | up-PE; S312F | up-PG; S290F | up-PH; S313F | up-PI; S305F | up-PJ; S312F | up-PK; S304F | up-PL; S289F | up-PM; S310F | up-PN; S313F | up-PO; S312F | up-PP; S304F | up-PQ; S304F | up-PR; S304F | up-PS; S222F | up-PT

Reported amino acid change:

S311F

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement. See FBrf0052459 figure 3 for protein sequence numbering.

(Fyrberg et al., 1990)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The core region of myofibrils of the flight muscles are well ordered, but peripheral thick and thin filaments are disordered.

      (Fyrberg et al., 1990)

      Heterozygotes have moderate flight ability and a normal wing posture. Homozygotes are flightless and approximately 23% have an abnormal wing posture.

      (Homyk and Emerson, 1988)

      Semidominant for flightlessness (Homyk and Emerson, 1988). homozygote wing phenotype normal: abnormal ( 3:1 ) heterozygote wing phenotype normal homozygote unable to fly semidominant for flightlessness

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      upwhu
      Name Synonyms
      Secondary FlyBase IDs
        References (5)