FB2026_02 , released June 18, 2026
Allele: Dmel\ptc17
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General Information
Symbol
Dmel\ptc17
Species
D. melanogaster
Name
FlyBase ID
FBal0028507
Feature type
allele
Associated gene
Dmel\ptc
Associated Insertion(s)
Carried in Construct
Also Known As
ptcIIX103
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Hidalgo and Ingham, 1990, Phillips et al., 1990, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: V834E.

(Strutt et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:8,662,660..8,662,660 [+]
Nucleotide change:

T8662660A

Amino acid change:

V834E | ptc-PA

Reported amino acid change:

V834E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Strutt et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      All flies carrying ptctuf-1 in trans to ptc17 have severely reduced, rough eyes, a highly enlarged head vertex (ocellar triangle, fronto-orbital plate and frons), outgrowths of head cuticle and large numbers of missing, misplaced or ectopic head bristles. ptc559.1/ptc17 flies have mildly reduced eyes, a slightly enlarged head vertex (ocellar triangle, fronto-orbital plate and frons) and low incidences of head cuticle outgrowths and ectopic or misplaced head bristles. They also occasionally lack one or both antennae.

      (Thomas and Ingham, 2003)

      100% of ptchdl/ptc17 transheterozygotes show head capsule defects.

      (Shyamala and Bhat, 2002)

      homozygous and hemizygous mutants display distortion in the costal cell and an increase in the distance between the L3 and L4 wing veins.

      (Strutt et al., 2001)

      homozygous lethal

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ptc17
      ptcIIX103
      (Shyamala and Bhat, 2002, Hidalgo and Ingham, 1990)
      ptcIIX
      (Phillips et al., 1990, Tearle and Nusslein-Volhard, 1987)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)