FB2026_03 , released September 17, 2026
Allele: Dmel\w+mW.hs
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General Information
Symbol
Dmel\w+mW.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0028611
Feature type
allele
Associated gene
Dmel\w
Associated Insertion(s)
Carried in Construct
Also Known As
whs
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct
(Heinrich et al., 1993, Klemenz et al., 1987)
Progenitor genotype
Cytology
Description

A 388bp fragment of the Hsp70 gene drives expression of a w mini-gene in which the size of the largest intron has been reduced to 356bp (deletion of 2.7kb XbaI/HindIII fragment).

(Klemenz et al., 1987)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eye colour: red even in the absence of heatshock.

      (Cryderman et al., 1999)

      Transformant heat shocked males exhibit homosexual courtship behaviour.

      (Zhang and Odenwald, 1995)

      Wild type eye pigmentation.

      (Kurkulos et al., 1994)

      The eye pigmentation of Df(1)w67c2 homozygotes carrying w+mW.hs is reduced if the flies are also carrying two copies of LTSV\RBZhs.w and are heat shocked for 1 hour at 37oC every 12 hours throughout development.

      (Heinrich et al., 1993)

      Eye colour: red, as homozygote. Eye colour: orange eyes that darken and become slightly mottled with age, as heterozygote.

      (Golic and Lindquist, 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The presence of Su(var)2051, Su(var)2052 or additional heterochromatin provided by an attached X suppress position effect variegation (PEV) of lines with insertions in centromeric regions or in the fourth chromosome. Insertions near the telomeres 2L, 2R or 3R show no suppression. Variegating transgenes show a reduction in accessibility to restriction enzyme digestion. This suggests that the chromatin packaging of an insert showing PEV is altered. Pericentric transgenes are packaged in a more regular array than euchromatic transgenes.

      (Wallrath and Elgin, 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      w+mW.hs
      w+mW
      whs
      (Hirosawa-Takamori et al., 2004, Sogame et al., 2003, Golic and Lindquist, 1989)
      Name Synonyms
      Secondary FlyBase IDs
        References (318)