FB2026_02 , released June 18, 2026
Allele: Dmel\Act88FG6AA7T
Open Close
General Information
Symbol
Dmel\Act88FG6AA7T
Species
D. melanogaster
Name
FlyBase ID
FBal0028747
Feature type
allele
Associated gene
Dmel\Act88F
Associated Insertion(s)
Carried in Construct
P{Act88FG6AA7T}
Key Links
Transgenic product class
missense_variant
(Reedy et al., 1989)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Reedy et al., 1989)
Mutagen
in vitro construct
(Reedy et al., 1989)
Progenitor genotype
Carried in construct
P{Act88FG6AA7T}
Cytology
Description

Construct: Amino acid replacement: G7A. Amino acid replacement: A7T.

(Reedy et al., 1989)
Allele components
Component
Use(s)
Encoded product / tool
Act88F
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Retards sarcomere assembly: peripheral thick and thin filaments are misregistered and do not incorporate into the Z-line. A myosin filament encounters thin filaments with the wrong polarity. Myosin heads can bind to the thin filaments by swivelling 180o relative to each other, implying that myosin bridges are as flexible as isolated molecules.

      (Reedy et al., 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Act88FG6AA7T
      Name Synonyms
      Secondary FlyBase IDs
        References (2)