FB2026_03 , released September 17, 2026
Allele: Dsim\mhr1
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General Information
Symbol
Dsim\mhr1
Species
D. simulans
Name
FlyBase ID
FBal0029520
Feature type
allele
Associated gene
Dsim\mhr
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Sawamura et al., 1993)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hybrid females from a cross of D.simulans females to D.melanogaster males are poorly viable. The lethality of these hybrids (which is embryonic) is rescued by D.simulans Dsim\mhr1. These rescued hybrids also show postembryonic lethality at 25oC. This postembryonic lethality is suppressed by D.melanogaster Hmr1.

      (Barbash et al., 2000)

      Suppresses hybrid female embryonic lethality of offspring from D.simulans females and D.melanogaster males.

      (Sawamura et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Rescued females show a temperature sensitive pupal lethality suggested to be due to effects of a mutation in a second unidentified gene. Allele identified in two laboratory strains.

      (Sawamura et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Dsim\mhr1
      mhr
      (Barbash et al., 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)