FB2025_05 , released December 11, 2025
Allele: Dmel\EgfrJE1
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General Information
Symbol
Dmel\EgfrJE1
Species
D. melanogaster
Name
FlyBase ID
FBal0029750
Feature type
allele
Associated gene
Dmel\Egfr
Associated Insertion(s)
Carried in Construct
Also Known As
topJE1, flbJE1, JE1
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Goldman-Levi et al., 1996, Clifford and Schupbach, 1992, Clifford and Schupbach, 1989, Schejter and Shilo, 1989)
Mutagen
ethyl methanesulfonate
(Clifford and Schupbach, 1994, Clifford and Schupbach, 1989)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C824T. Amino acid replacement: S152F.

(Clifford and Schupbach, 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:21,555,266..21,555,266 [+]
Nucleotide change:

C21555266T

Reported nucleotide change:

C824T

Amino acid change:

S152F | Egfr-PA; S201F | Egfr-PB

Reported amino acid change:

S152F

(Clifford and Schupbach, 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos exhibit a severe germband retraction phenotype, virtually all embryos are curled into round, denticle less balls. Internal tissues of the germband exhibit abnormalities. Kr staining reveals abnormalities in the amnioserosa.

      (Goldman-Levi et al., 1996)

      Enhances the female sterility and adult morphological defects of Egfrt1. Rarely survives as transheterozygote with the semi-viable Egfrtop-CA allele.

      (Clifford and Schupbach, 1994)

      The mesoderm is less uniform than in wild-type embryos at the extended germ band stage. It is arranged in clusters of cells that are not always connected, due to disruptions in the regions opposite the parasegmental grooves.

      (Raz and Shilo, 1992)

      Fusion of the longitudinal connectives and loss of the horizontal commissures of the CNS is seen in homozygous EgfrJE1 embryos at the retracted germ-band stage.

      (Zak et al., 1990)

      Homozygotes and hemizygotes display a severe 'flb' phenotype. Embryos produced from heteroallelic combination with Egfrt1 have a severe ventralised phenotype, reduction in size of their dorsal appendage.

      (Clifford and Schupbach, 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Mutation of Egfr that affects the gene function required for imaginal disc derivatives, a class IV lesion.

      (Clifford and Schupbach, 1989)

      Germline clone analysis indicates that there is very little, if any, requirement for Egfr in the germline.

      (Clifford and Schupbach, 1992)

      Class I allele. This allele was originally thought to be a class IV allele, but the weak wing venation abnormalities observed for the allele were due to suppression by a px mutation on the same chromosome.

      (Clifford and Schupbach, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      EgfrJE1
      JE1
      (Raz et al., 1991, Zak et al., 1990)
      flbJE1
      (Goldman-Levi et al., 1996, Raz and Shilo, 1992)
      l(2)57DEFa-1
      topJE1
      (Clifford and Schupbach, 1994, Clifford and Schupbach, 1992, Clifford and Schupbach, 1989)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)