FB2026_02 , released June 18, 2026
Allele: Dmel\EgfrSH2
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General Information
Symbol
Dmel\EgfrSH2
Species
D. melanogaster
Name
FlyBase ID
FBal0029751
Feature type
allele
Associated gene
Dmel\Egfr
Associated Insertion(s)
Carried in Construct
Also Known As
topSH2
Key Links
Genomic Maps

Allele class

heat sensitive loss of function allele

Mutagen
Nature of the Allele
Allele class

heat sensitive loss of function allele

(Clifford and Schupbach, 1994)
Mutagen
ethyl methanesulfonate
(Clifford and Schupbach, 1989)
ethyl nitrosourea
(Clifford and Schupbach, 1994)
Progenitor genotype
Cytology
Description

Nucleotide substitution: T839A. Amino acid replacement: L157Q.

(Clifford and Schupbach, 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:21,555,281..21,555,281 [+]
Nucleotide change:

T21555281A

Reported nucleotide change:

T839A

Amino acid change:

L157Q | Egfr-PA; L206Q | Egfr-PB

Reported amino acid change:

L157Q

(Clifford and Schupbach, 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Suppresses the dominant "Ellipse" phenotype. Homozygous clones in the eye do not survive to the adult stage.

      (Baker and Rubin, 1989)

      Homozygotes display a weak 'flb' phenotype and hemizygotes display an intermediate 'flb' phenotype. Embryos produced from heteroallelic combination with Egfrt1 have a severe ventralised phenotype, reduction in size of their dorsal appendage. When in combination with Egfrt1 or Egfrt2 individuals display a weak female sterile phenotype.

      (Clifford and Schupbach, 1989)

      Weak lethal phenotype: embryos lack some head and telson structures and have some development of the ventral cuticle.

      (Schejter and Shilo, 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Weak allele.

      (Schejter and Shilo, 1989)

      Mutation of Egfr that affects the gene function required for oogenesis, a class III lesion. The allelic series for class III lesions: EgfrSH2 < Egfrtop-38 < Egfrf12.

      (Clifford and Schupbach, 1989)

      Class III allele.

      (Clifford and Schupbach, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      EgfrSH2
      SH2
      (Raz et al., 1991)
      l(2)57DEFa-4
      (Baker and Rubin, 1989)
      topSH2
      (Clifford and Schupbach, 1994, Clifford and Schupbach, 1989)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)