FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Est-6S
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General Information
Symbol
Dmel\Est-6S
Species
D. melanogaster
Name
FlyBase ID
FBal0029760
Feature type
allele
Associated gene
Dmel\Est-6
Associated Insertion(s)
Carried in Construct
Also Known As
S, EST6-S
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
natural population
(Parkash et al., 1993, Parkash et al., 1993)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying Est-6S are more resistant to high temperatures than flies carrying Est-6F.

      (Totskii et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (4)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The biochemical properties of the Est-6F and Est-6S allozymes have been studied. The two allozymes have differences in their physical and kinetic properties that may be related to the natural distribution of these two variants. Est-6S is more thermostabile than Est-6F at temperatures above 40oC.

      (White et al., 1988)

      Gramoxone increases the frequency of the Est-6S allele and decreases the frequency of the Est-6F allele in the offspring of treated flies.

      (el Abidin Salam et al., 1993)

      The frequency of the AdhS allele in Eurasian natural populations decreases towards the centre of the continent and is positively correlated with temperature of the coldest month and the rainfall of the driest month.

      (Bublii et al., 1994)

      Electrophoretic mobility of Est-6S protein is less than that of Est-6F protein.

      (Totskii et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      EST-6-S
      (Bublii et al., 1994)
      EST6-S
      (Labate et al., 1989, Oakeshott et al., 1989)
      Est-6S
      S
      (Bubli et al., 1996, el Abidin Salam et al., 1993)
      Name Synonyms
      Secondary FlyBase IDs
        References (17)