FlyBase Allele Report: Dmel\Khc[1ts]

General Information

Symbol

Dmel\Khc^1ts

Species

D. melanogaster

Name

FlyBase ID

FBal0029873

Feature type

allele

Associated gene

Dmel\Khc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

heat sensitive loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

heat sensitive loss of function allele

(Saxton et al., 1991)

Mutagen

ethyl methanesulfonate

(Saxton et al., 1991)

Progenitor genotype

Cytology

Description

Point mutation.

(Saxton et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior

(Hurd and Saxton, 1996)

lethal | heat sensitive

(Saxton et al., 1991)

suppressor of variegation | dominant, with P{SUPor-P}KV00108

(Swenson et al., 2016)

Phenotype Manifest In

axon

(Hurd and Saxton, 1996)

neuromuscular junction

(Hurd and Saxton, 1996)

Detailed Description

Statement

Reference

Khc^1ts/+ suppresses position effect variegation at the w locus caused by P{SUPor-P}KV00108.

(Swenson et al., 2016)

Mutation causes organelle-filled axonal swellings that exhibit abnormal accumulation of nerve terminal proteins, including syt.

(Hurd and Saxton, 1996)

Larval growth abnormalities and lack of mobility. At 29^oC individuals exhibit slow sluggish crawling behaviour and sometimes develop paralysed tails. At 25^oC adults are viable and fertile but less active than wild type and flightless: wings are slightly curved, held up from horizontal and hardly move.

(Saxton et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Khc^1ts is a suppressor of abnormal behavior phenotype of Sh¹⁴

(Hurd et al., 1996)

Khc^1ts is a suppressor of abnormal behavior | recessive phenotype of eag¹

(Hurd et al., 1996)

Phenotype Manifest In

Suppressor of

Statement

Reference

Khc^1ts is a suppressor of leg phenotype of Sh¹⁴

(Hurd et al., 1996)

Khc^1ts is a suppressor of leg phenotype of eag¹

(Hurd et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

Suppresses the leg shaking of Sh¹⁴ and eag¹ mutants at 29^oC but not 25^oC.

(Hurd et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Khc^1ts is rescued by Khc^+t7.5

(Saxton et al., 1991)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

31994

w^*; Khc^1ts/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Khc^1ts

(Sarov et al., 2016, Swenson et al., 2016)

khc1^ts

(Henthorn et al., 2011)

khc^1ts

(Henthorn et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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