FlyBase Allele Report: Dmel\N[ΔCDC10.hs]

General Information

Symbol

Dmel\N^ΔCDC10.hs

Species

D. melanogaster

Name

FlyBase ID

FBal0029962

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

P{N-ΔCDC10}

Also Known As

Δcdc10, hs-N^Δcdc10

Key Links

Transgenic product class

inframe_deletion

(Rebay et al., 1993)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Rebay et al., 1993)

Mutagen

in vitro construct

(Fortini and Artavanis-Tsakonas, 1994, Lieber et al., 1993, Rebay et al., 1993)

Progenitor genotype

Carried in construct

P{N-ΔCDC10}

Cytology

Description

Deletion within the cytoplasmic domain of the N protein.

(Lieber et al., 1993)

An Hsp70 promoter driving N cDNA deleted for six cdc10/ankyrin repeats and approximately 100 upstream amino acids.

(Rebay et al., 1993)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory | heat sensitive

(Ge et al., 2004)

lethal | neurogenic phenotype | heat sensitive

(Lieber et al., 1993)

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing N^ΔCDC10.hs (using 37^oC heat shock) show normal reactivity to electric shock and normal olfactory acuity (to methylcyclohexanol). These flies show normal learning scores in a Pavlovian learning and memory assay. However, they show a significant reduction in one-day memory after spaced training compared to controls. One day memory after massed training in flies expressing N^ΔCDC10.hs using heat shock is not different from controls, indicating that long term memory, but not anesthesia-resistant memory, is affected.

(Ge et al., 2004)

Potentiates the effects of dsh^hs.PA in the wing.

(Axelrod et al., 1996)

Strong neurogenic phenotype in N⁺ embryos. Unable to rescue the cuticle phenotype of N^264-47 embryos.

(Lieber et al., 1993)

Heat shock causes aberrant wing vein pattern, wing nicking, rough eye and missing thoracic microchaetae. This allele behaves almost exactly like N^ECN.hs, suggesting that the cdc10 repeat region is essential for N intracellular function.

(Rebay et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Incomplete N protein.

(Lieber et al., 1993)

Carried in plasmid, used to transfect S2 cells.

(Fortini and Artavanis-Tsakonas, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

N^ΔCDC10.hs

N^Δcdc10

(Axelrod et al., 1996)

hs-N^Δcdc10

(Matsuno et al., 2015)

ΔCDC10

(Lieber et al., 1993)

Δcdc10

(Fortini and Artavanis-Tsakonas, 1994)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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