FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fors1
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General Information
Symbol
Dmel\fors1
Species
D. melanogaster
Name
FlyBase ID
FBal0031281
Feature type
allele
Associated gene
Dmel\for
Associated Insertion(s)
Carried in Construct
Also Known As
s(R)136
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
gamma ray
(de Belle et al., 1989)
Progenitor genotype
forR
(de Belle et al., 1989)
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fors1/for+ pupae show tachycardia at temperatures above 25oC. Linear regression of heart rate on temperature is positive as in wild type, but the slope is significantly higher. Injection of serotonin or norepinephrine increases the heart rate in the mutant pupae, but for serotonin, the amount of change is significantly less than in wild-type controls.

      (Johnson et al., 2002)

      In larval and adult tests, homozygotes show sitter-type behavior.

      (Pereira and Sokolowski, 1993)

      Homozygous or fors1/fors larvae have a "sitter" phenotype. fors1/forR larvae have a "rover" phenotype.

      (de Belle et al., 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      See also de Belle et al., 1989, Genetics 123:157--163 . Chromosome carrying fors1 has been cleaned of second site lethal originally on chromosome carrying s(R)136 allele, by recombination.

      (Pereira and Sokolowski, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      S(R)136
      (de Belle et al., 1989)
      fors(R)136
      (de Belle et al., 1993)
      fors1
      s(R)136
      (Pereira and Sokolowski, 1993)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)