FB2026_02 , released June 18, 2026
Allele: Dmel\haync2rv8
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General Information
Symbol
Dmel\haync2rv8
Species
D. melanogaster
Name
FlyBase ID
FBal0031460
Feature type
allele
Associated gene
Dmel\hay
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Mounkes et al., 1992, Regan and Fuller, 1990)
Progenitor genotype
haync2
(Mounkes and Fuller, 1999, Mounkes et al., 1992, Regan and Fuller, 1990)
Cytology
Description

Amino acid replacement: E278K. Nucleotide substitution: changing codon 278 from GAG to AAG.

(Mounkes and Fuller, 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:10,632,284..10,632,284 [+]
Nucleotide change:

G10632284A

Reported nucleotide change:

G?A

Amino acid change:

E273K | hay-PA; E273K | hay-PB

Reported amino acid change:

E278K

Comment:

The amino acid numbering differs between FBrf0108244 and the reference sequence. The positions and nature of the base substitutions in the mutants are derived from the sequence in Fig. 1 and from Table 1, and provide unambiguous assignments.

(Mounkes and Fuller, 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Cockayne syndrome
      CEA
      (Mounkes et al., 1992)
      model of  xeroderma pigmentosum
      CEA
      (Mounkes et al., 1992)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes are lethal at 25[o]C.

      (Aguilar-Fuentes et al., 2008)

      haync2/haync2rv8 animals show 49.7% viability. 11.1% of haync2/haync2rv8 adults have deformed and fragile macrochaetae and microchaetae, 15.3% have a reduction of the endocuticular layer of the abdominal cuticle and 0% show loss of wing marginal regions and blistered wings.

      (Merino et al., 2002)

      Mutants are UV sensitive.

      (Mounkes and Fuller, 1999)

      Viable. Flies heterozygous for this allele and a deficiency for hay show increased sensitivity to ultraviolet irradiation.

      (Mounkes et al., 1992)

      Viable as hemizygotes: partially restore hay function toward wild type.

      (Regan and Fuller, 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      haync2rv8 has lethal | recessive | heat sensitive phenotype, non-suppressible by Tfb5Hsp83.PAF

      (Aguilar-Fuentes et al., 2008)
      Enhancer of
      Statement
      Reference

      hay[+]/haync2rv8 is an enhancer of visible phenotype of Cdk7P140S

      (Merino et al., 2002)
      Other
      Statement
      Reference

      Cdk7P140S, hay[+]/haync2rv8 has visible phenotype

      (Merino et al., 2002)

      Cdk7P140S, haync2rv8 has visible phenotype

      (Merino et al., 2002)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      hay[+]/haync2rv8 is an enhancer of wing phenotype of Cdk7P140S

      (Merino et al., 2002)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies carrying Cdk7P140S in a heterozygous Df(1)JB254 P{snf+,dhd+} background (the Df(1)JB254 chromosome is deficient for Cdk7, snf and dhd and snf and dhd function is provided by the P{snf+,dhd+} transgene) at the restrictive temperature that are also carrying one copy of haync2rv8 show brittle bristle and cuticle defect phenotypes. The penetrance of the wing phenotypes (shape deformities and size reduction) seen in flies carrying Cdk7P140S in a heterozygous Df(1)JB254 P{snf+,dhd+} background at the restrictive temperature is increased if they are also carrying one copy of haync2rv8. These animals do not show abnormal amounts of apoptosis in the imaginal discs or central nervous system.

      (Merino et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      haync2rv8
      (Aguilar-Fuentes et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)