FB2026_02 , released June 18, 2026
Allele: Dmel\hhAE
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General Information
Symbol
Dmel\hhAE
Species
D. melanogaster
Name
FlyBase ID
FBal0031482
Feature type
allele
Associated gene
Dmel\hh
Associated Insertion(s)
P{?'PZ}hhAE
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Lee et al., 1992)
Mutagen
Delta2-3 transposase
(Lee et al., 1992)
Progenitor genotype
P{PZ}hhP30
(Lee et al., 1992)
hhP30
(Lee et al., 1992)
Associated Insertion(s)
P{?'PZ}hhAE
Cytology
Description

Deletion beginning in P{PZ}hhP30 (i.e. at coordinate 0) extending to between +0.8 and +2.0kb. Deletion of sequences beginning in the P-element insertion and extending to between position +0.8 to +2.0 (coordinate 0 is the P{lacZ} insertion of hhP30), removing the hh promoter and part of the coding region.

(Lee et al., 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Extreme hh cuticle phenotype when heterozygous with hh9, or when homozygous. Head segments fail to involute, naked cuticle portion of segment lost causing half size embryos with a lawn of denticles. When heterozygous with hh4 at 18oC, adults show mild eye phenotype, but there is no mutant eye phenotype when heterozygous with hhbar3. Homozygous embryos exhibit failure head involution and loss of naked cuticle from the posterior surface of each segment. Lethal when in homozygous or heterozygous combination with hh5, hh8 or hh9. Transheterozygotes with hh4 produce some adult survivors, at 18oC they display an eye phenotype.

      (Lee et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      hhAE
      Name Synonyms
      Secondary FlyBase IDs
        References (1)