FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pntrM254
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General Information
Symbol
Dmel\pntrM254
Species
D. melanogaster
Name
FlyBase ID
FBal0032469
Feature type
allele
Associated gene
Dmel\pnt
Associated Insertion(s)
P{A92}pntrM254
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Klambt, 1993)
Mutagen
Delta2-3 transposase
(Klambt, 1993, Scholz et al., 1993)
Progenitor genotype
Associated Insertion(s)
P{A92}pntrM254
Cytology
Description

P element inserted into the 5' region of the pnt transcription unit.

(Klambt, 1993)

P-element insertion into the promoter region of the P1 pnt transcript.

(Scholz et al., 1993)
Allele components
Component
Use(s)
Inserted element
P{A92}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant embryos show a mild defasciculation of axons in the central nervous system.

      (Shandala et al., 2003)

      Glial cells fail to differentiate properly. Reduced numbers of dorsal medial cells form. Data suggests that the midline glial cells perform an important function during the induction of the dorsal medial cells.

      (Luer et al., 1997)

      Differentiation of longitudinal glial cells is affected.

      (Klaes et al., 1994)

      Tracheal dorsal trunks fail to form in the embryo, due to failure in migration of trachea cells. Embryonic muscles 4, 11, 19 and 20 are absent and muscles 15, 16 and 17 are small and displaced (though note that the ventral epidermis is affected in pnt mutants). Commissures in the CNS are fused.

      (Klambt, 1993)

      CNS and tracheal phenotype.

      (Scholz et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      C.S. Goodman.

      (Scholz et al., 1993)
      Comments
      Comments

      Analysis of excess cardioblast phenotype provides an allelic series:pntS012309, pnt2 > pntRR112, pntrM254 > pntΔ88, pnt07825.

      (Alvarez et al., 2003)

      Dysgenesis-induced excisions of the P element revert the phenotype to wild type.

      (Klambt, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pntRM254
      (Alvarez et al., 2003)
      pntrM254
      Name Synonyms
      Secondary FlyBase IDs
        References (8)