FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Klp61Furc-3
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General Information
Symbol
Dmel\Klp61Furc-3
Species
D. melanogaster
Name
FlyBase ID
FBal0032987
Feature type
allele
Associated gene
Dmel\Klp61F
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Wilson et al., 1997)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
DQ782381
ABG91086
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The brains of hemizygous larvae have a reduced frequency of anaphase figures, and an increased frequency of polyploid figures and overcondensed chromosomes compared to wild-type. The brains are very small compared to wild-type and there are no recognisable imaginal discs.

      (Wilson et al., 1997)

      Primary defect is an inability of centrosomes to separate and organise a bipolar spindle. Mitotic figures are highly polyploid consisting of overcondensed chromosomes in apparent monopolar configurations.

      (Wilson and Fuller, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Klp61F alleles form the following phenotypic series, from the most to the least severe: Klp61Furc-1 > Klp61Furc-3 > Klp61F06836, Klp61F07012 > Klp61F06345 > Klp61Furc-4.

      (Wilson et al., 1997)
      External Crossreferences and Linkouts ( 2 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      KLP61F6
      (Wilson et al., 1997)
      Klp61Furc-3
      urc3
      (Wilson et al., 1997)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)