FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Egfrtop-EE38
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General Information
Symbol
Dmel\Egfrtop-EE38
Species
D. melanogaster
Name
FlyBase ID
FBal0033672
Feature type
allele
Associated gene
Dmel\Egfr
Associated Insertion(s)
Carried in Construct
Also Known As
topEE38
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Clifford and Schupbach, 1994, Clifford and Schupbach, 1989)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C1099T. Amino acid replacement: R244C.

(Clifford and Schupbach, 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:21,555,541..21,555,541 [+]
Nucleotide change:

C21555541T

Reported nucleotide change:

C1099T

Amino acid change:

R244C | Egfr-PA; R293C | Egfr-PB

Reported amino acid change:

R244C

(Clifford and Schupbach, 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous adult viable.

      (Clifford and Schupbach, 1994)

      Homozygotes and hemizygotes are viable. Adults exhibit milder eye defects than would be expected from the severity of the wing and haltere defects.

      (Clifford and Schupbach, 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Mutation of Egfr that affects the gene function required for imaginal disc derivatives, a class IV lesion.

      (Clifford and Schupbach, 1989)

      Class IV allele.

      (Clifford and Schupbach, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Egfrtop-EE38
      topEE38
      (Clifford and Schupbach, 1994, Clifford and Schupbach, 1989)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)