FB2026_02 , released June 18, 2026
Allele: Dmel\RanGAPSd.tPa
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General Information
Symbol
Dmel\RanGAPSd.tPa
Species
D. melanogaster
Name
FlyBase ID
FBal0034010
Feature type
allele
Associated gene
Dmel\RanGAP
Associated Insertion(s)
Carried in Construct
P{Sd.P}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Powers and Ganetzky, 1991)
Progenitor genotype
RanGAPSd
(Powers and Ganetzky, 1991)
Carried in construct
P{Sd.P}
Cytology
Description

Construct: Contains a 12kb EcoRI fragment including the Dp(2;2)RanGapSD tandem duplication.

(Powers and Ganetzky, 1991)
Allele components
Component
Use(s)
Encoded product / tool
RanGAP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Construct allows low levels of segregation distortion; the segregation ratio for the second chromosome in Rspi/Rspss males carrying P{Sd.P}, where k is the proportion of Rspi bearing progeny among the total offspring, is k= 0.597 +/- 0.014 (P{Sd.P}2) and k= 0.604 +/- 0.012 (P{Sd.P}3), which is significantly different from the control value of k= 0.497 +/- 0.008. The reduced level of distortion could be due to lack of drive elements. In the presence of Dp(2;Y)R10 (carrying E(SD)1 and lacking RanGAPSd), and Df(2L)Sd37 (lacking RanGAPSd and E(SD)1, but M(SD)1 and St(SD)1 are present), high levels of distortion are measured. RanGAPSd.tPa induces high levels of segregation distortion in the presence of the SD-5[R7] chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss or Rsps.

      (McLean et al., 1994)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Alone this is not sufficient to produce detectable distorted segregation of an Rsps bearing chromosome.

      (Powers and Ganetzky, 1991)

      Effect is insertion independent and is seen for both P{Sd.P}2 and P{Sd.P}3.

      (McLean et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      RanGAPSd.tPa
      RanGapSd.tPa
      SdcPa
      SdtPa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)