FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\bcdGCN4.x3
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General Information
Symbol
Dmel\bcdGCN4.x3
Species
D. melanogaster
Name
FlyBase ID
FBal0034303
Feature type
allele
Associated gene
Dmel\bcd
Associated Insertion(s)
Carried in Construct
P{bcd-GCN4.x3}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Ronchi et al., 1993)
Progenitor genotype
Carried in construct
P{bcd-GCN4.x3}
Cytology
Description

Three copies of the activation domain from the Saccharomyces cerevisiae GCN4 gene are fused 282bp downstream of the end of the homeobox in the context of a complete bcd genomic fragment.

(Ronchi et al., 1993)
Allele components
Component
Use(s)
Encoded product / tool
bcd
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos carrying P{bcd-GCN4.x3} show defective head structures and tor-dependent repression of bcd target gene expression does not occur.

      (Janody et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      This modified bcd protein bypasses regulation by the terminal system, suggesting that phl-dependent inhibition is at the level of transcriptional regulation and not DNA binding.

      (Ronchi et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      bcd::Scer\GCN4x3
      bcdGCN4.x3
      bcdx3.T:Scer\GCN4
      Name Synonyms
      Secondary FlyBase IDs
        References (2)