FlyBase Allele Report: Dmel\pk[pk-sple-6]

General Information

Symbol

Dmel\pk^pk-sple-6

Species

D. melanogaster

Name

FlyBase ID

FBal0035406

Feature type

allele

Associated gene

Dmel\pk

Associated Insertion(s)

Carried in Construct

Also Known As

pk-sple⁶

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Gubb et al., 1999, Heitzler et al., 1993)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Gubb et al., 1999, Heitzler et al., 1993)

abnormal visual behavior

(Heitzler et al., 1993)

visible | recessive

(Gubb et al., 1999)

Phenotype Manifest In

abdomen

(Gubb et al., 1999)

eye

(Gubb et al., 1999, Heitzler et al., 1993)

leg

(Gubb et al., 1999)

leg & macrochaeta

(Heitzler et al., 1993)

leg & trichome

(Heitzler et al., 1993)

scutum

(Gubb et al., 1999)

wing

(Gubb et al., 1999)

wing hair

(Heitzler et al., 1993)

Detailed Description

Statement

Reference

Causes no embryonic phenotype even when homozygous mutant embryos develop from homozygous mutant mothers. Has a weak polarity phenotype in the wing, notum, abdomen, eye and legs. Denticle belt morphology and denticle orientation remains wild-type.

(Gubb et al., 1999)

Sections of pk^pk-sple-6 mutant eyes show a disturbed ommatidial polarity within each ommatidium having the normal arrangement of photoreceptor cells.

(Zheng et al., 1995)

Rough eyes and weak pk and spiny leg phenotypes.

(Heitzler et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

pk[+]/pk^pk-sple-6 is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Jenny et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

pk[+]/pk^pk-sple-6 is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Jenny et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The planar cell polarity defects seen in the eyes of flies expressing dgo^Scer\UAS.cFa under the control of Scer\GAL4^hs.2sev are dominantly enhanced by pk^pk-sple-6/+.

(Jenny et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

101551

pk^pk-sple-6 bw^D / SM5

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

pk-sple⁶

(Zheng et al., 1995, Heitzler et al., 1993)

pk⁶

pk^pk-sple-6

pk^pk-sple6

(Jenny et al., 2005)

sple⁶

Name Synonyms

Secondary FlyBase IDs

FBal0035675

References (4)

Report Sections

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