FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MtnA3
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General Information
Symbol
Dmel\MtnA3
Species
D. melanogaster
Name
FlyBase ID
FBal0038918
Feature type
allele
Associated gene
Dmel\MtnA
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
natural population
(Stephan et al., 1994)
Progenitor genotype
Cytology
Description

The mutation in MtnA3 with respect to MtnA1 is thought to reduce Cadmium binding.

(Maroni et al., 1995)

Amino acid replacement: D40K.

(Maroni et al., 1995)

MtnA3 shows a number of sequence changes relative to MtnA1 : two single base changes in the promoter region, amino acid replacement E40K, a single base change and an extra 49bp segment in the 3' untranslated region.

(Theodore et al., 1991)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:9,783,864..9,783,864 [-]
Nucleotide change:

G9783864A

Amino acid change:

E40K | MtnA-PA; E40K | MtnA-PB

Reported amino acid change:

D40K

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Author statement: There are also two single base changes in the promoter region, and one in the 3' untranslated region. The 3' untranslated region is 49bp longer than in MtnA1.

(Theodore et al., 1991)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Tolerance to Cadmium the same as that as for MtnA1, despite the fact that MtnA1 is expressed at three-times the level of MtnA3.

      (Maroni et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Restriction analysis of the MtnA gene from a number of Drosophila species suggests that MtnA3 is the ancestral allele, from which MtnA1 is derived. MtnA1Dp appears to be derived from MtnA1. These two changes seem to have occurred in non-African populations.

      (Theodore et al., 1991)

      Presumed the ancestral allele, there is presumed to be a one step transition to MtnA1 and a further step to MtnA1Dp.

      (Stephan et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mtn.3
      (Theodore et al., 1991)
      MtnA3
      Name Synonyms
      Secondary FlyBase IDs
        References (5)