FlyBase Allele Report: Dmel\ovo[D1-18]

General Information

Symbol

Dmel\ovo^D1-18

Species

D. melanogaster

Name

FlyBase ID

FBal0039730

Feature type

allele

Associated gene

Dmel\ovo

Associated Insertion(s)

Carried in Construct

P{ovoD1-18}

Key Links

Transgenic product class

missense_variant

(Chou et al., 1993)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Chou et al., 1993)

Mutagen

in vitro construct

(Chou et al., 1993)

Progenitor genotype

ovo^D1

(Chou et al., 1993)

Carried in construct

P{ovoD1-18}

Cytology

Description

Construct: 18kb fragment carrying ovo^D1.

(Chou et al., 1993)

Allele components

Component

Use(s)

Encoded product / tool

ovo

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | dominant

(Chou and Perrimon, 1996, Brizuela et al., 1994, Chou et al., 1993)

Phenotype Manifest In

Detailed Description

Statement

Reference

Heat induced expression of P{ovoD1-18} P{FRT(w^hs)} chromosome using P{hsFLP} causes a dominant female sterile phenotype, no eggs are laid by heterozygous females, oogenesis is blocked before vitellogenesis. Heat induced expression of P{ovoD1-18} P{FRT(w^hs)} chromosome using P{hsFLP} allows 100% recovery of germline clones (GLC) (compare to 1-2% following X ray irradiation). Eggs are laid by females derived from germline recombination events.

(Chou and Perrimon, 1996)

Heterozygotes have pale orange eyes. One copy of P{ovoD1-18} causes atrophic ovaries, the few females with normal ovaries lay abnormal eggs that have fused dorsal appendages and are flaccid. Three copies causes sterility.

(Chou et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions