FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pc::Su(var)205hs.lacZ
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General Information
Symbol
Dmel\Pc::Su(var)205hs.lacZ
Species
D. melanogaster
Name
FlyBase ID
FBal0042696
Feature type
allele
Associated gene
Pc::Su(var)205
Associated Insertion(s)
Carried in Construct
P{HP1-Pc}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Platero et al., 1996, Platero et al., 1995)
Progenitor genotype
Carried in construct
P{HP1-Pc}
Cytology
Description

A chimeric protein in which the chromodomain of Su(var)205 (amino acids 21-67) has been replaced by the chromodomain of Pc (amino acids 24-69), tagged with lacZ.

(Platero et al., 1995)
Allele components
Component
Use(s)
Encoded product / tool
Pc::Su(var)205
Tagged with
lacZ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Promotes heterochromatin induced position effect variegation.

      (Platero et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Chimeric protein can recruit Su(var)205 to ectopic sites and can substitute for the Su(var)205 chromo domain in a functional assay for heterochromatin mediated gene silencing.

      (Platero et al., 1995)

      Pc::Su(var)205hs.T:Ecol\lacZ protein recruits Psc protein to ectopic sites in the heterochromatin.

      (Platero et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Pc::Su(var)205hs.T:Ecol\lacZ
      Pc::Su(var)205hs.T:lacZ
      Pc::Su(var)205hs.lacZ
      Name Synonyms
      Secondary FlyBase IDs
        References (7)