FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\discohs.PC
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General Information
Symbol
Dmel\discohs.PC
Species
D. melanogaster
Name
heat shock construct of Campos
FlyBase ID
FBal0042974
Feature type
allele
Associated gene
Dmel\disco
Associated Insertion(s)
Carried in Construct
P{hs-disco}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Grether et al., 1995, White et al., 1994)
Progenitor genotype
Carried in construct
P{hs-disco}
Cytology
Description
Allele components
Component
Use(s)
Encoded product / tool
disco
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The ectopic expression of discohs.PC after heat-shock treatment results in gross morphological abnormalities in later embryogenesis, including defects in the central and peripheral nervous system and aberrant development of the optic lobe primordia. The most pronounced defects are seen when heat-shocked between 4 and 8 hours of development.

      (Lee et al., 1999)

      Failed to induce programmed cell death (PCD) in Df(3L)H99 embryos.

      (Grether et al., 1995)

      No detectable increase in cell death of Df(3L)H99 embryos.

      (White et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      A. Campos and H. Steller.

      (Grether et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      discohs.PC
      Name Synonyms
      heat shock construct of Campos
      (Grether et al., 1995)
      Secondary FlyBase IDs
        References (3)