FlyBase Allele Report: Dmel\for[lsR92]

General Information

Symbol

Dmel\for^lsR92

Species

D. melanogaster

Name

FlyBase ID

FBal0043076

Feature type

allele

Associated gene

Dmel\for

Associated Insertion(s)

Carried in Construct

Also Known As

for^l(92)

Key Links

Allele class

Mutagen

gamma ray

Nature of the Allele

Allele class

Mutagen

gamma ray

(Sokolowski and Hansell, 1992, de Belle et al., 1989)

Progenitor genotype

for^R

(Sokolowski and Hansell, 1992, de Belle et al., 1989)

Cytology

Polytene chromosomes normal.

(de Belle et al., 1989)

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

axon terminus | larval stage

(Renger et al., 1999)

Detailed Description

Statement

Reference

Large amplitude (up to 5nA) spontaneous ejcs occur at high frequency, evoked ejcs that are time-locked to the stimulus show significantly greater amplitude. TTX suppresses the large spontaneous ejcs and supernumerary discharges after the time-locked evoked ejc, but not the spontaneous mini ejcs, indicating that enhanced nerve excitability plays a role in the asynchronous synaptic discharge in sitter mutants. The number of ectopic nerve points in the muscles of for^s, for^s2 and for^lsR92 correlates with excitability levels of both central neurons and motor axons.

(Renger et al., 1999)

Larvae homozygous for the "sitter" alleles for^s or for^lsR92 move equally as well as larvae homozygous for the "rover" for^R allele on non-nutritive substrates. Larvae homozygous for the for^R allele take more strides, not longer ones, than larvae carrying for^s or for^lsR92 on foraging substrates.

(Sokolowski and Hansell, 1992)

Homozygous or for^lsR92/for^s larvae have a "sitter" phenotype. for^lsR92/for^R larvae have a "rover" phenotype. Homozygotes die after the grey wing stage of pupal development.

(de Belle et al., 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

for^s2

(Shaver et al., 1998)

Comments

Fails to complement the increased olfactory trap response of for^s2 adults.

(Shaver et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

The differences in larval locomotion during foraging in larvae carrying different alleles of the for locus cannot be explained on the basis of muscle usage alone, and it is more likely that for affects larval ability to perceive or respond to the foraging environment.

(Sokolowski and Hansell, 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

S(R)92

(de Belle et al., 1989)

for^l(92)

(Shaver et al., 1998, Sokolowski and Hansell, 1992)

for^ls(R)92

(de Belle et al., 1993)

for^lsR92

for^s92

(Renger et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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