FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sema2ahs.Tl
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General Information
Symbol
Dmel\Sema2ahs.Tl
Species
D. melanogaster
Name
FlyBase ID
FBal0044333
Feature type
allele
Associated gene
Dmel\Sema2a
Associated Insertion(s)
Carried in Construct
P{pCaSpeR-Toll-semaII}
Key Links
Transgenic product class
wild_type
(Matthes et al., 1995)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Matthes et al., 1995)
Mutagen
in vitro construct
(Matthes et al., 1995)
Progenitor genotype
Carried in construct
P{pCaSpeR-Toll-semaII}
Cytology
Description

Construct: 2.6kb Asp718 XbaI fragment carrying the entire open reading frame and 400bp of 5' and 230bp of 3' untranslated sequence. Expression of the fragment is driven by 6.5kb NotI fragment of the Tl enhancer and Hsp70 promoter.

(Matthes et al., 1995)
Allele components
Component
Use(s)
Encoded product / tool
Sema2a
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression prevents RP3 innervation to muscles 7 and 6.

      (Winberg et al., 1998)

      Abnormal pattern of innervation of muscles 7 and 6 in segment A2 and muscle 31 in segment A1. Abnormal Rp3 and RP1 growth cone is seen by absence of normal terminal arbor on these muscles.

      (Matthes et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Sema-2ahs.Tl
      Sema2ahs.Tl
      (Winberg et al., 1998)
      sema-IIhs.Tl
      Name Synonyms
      Secondary FlyBase IDs
        References (2)