FB2026_03 , released September 17, 2026
Allele: Dmel\Polr2AIIt
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General Information
Symbol
Dmel\Polr2AIIt
Species
D. melanogaster
Name
FlyBase ID
FBal0045041
Feature type
allele
Associated gene
Dmel\Polr2A
Associated Insertion(s)
Carried in Construct
P{Polr2AIIt}
Key Links
Transgenic product class
missense_variant
(Brickey and Greenleaf, 1995)
stop_gained
(Brickey and Greenleaf, 1995)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Brickey and Greenleaf, 1995)
stop_gained
(Brickey and Greenleaf, 1995)
Mutagen
in vitro construct
(Brickey and Greenleaf, 1995)
Progenitor genotype
Carried in construct
P{Polr2AIIt}
Cytology
Description

Fragment that encompasses the Polr2A transcription unit. The coding sequence contains the R741H mutation found in the Polr2A4 allele (which confers resistance to amanitin in Polr2A4 flies). In addition, an oligonucleotide has been introduced upstream of the CTD heptad repeat domain; this introduces 7 novel amino acids (QQFFGLM) followed by two stop codons, truncating the protein before the CTD repeats.

(Brickey and Greenleaf, 1995)
Allele components
Component
Use(s)
Regulatory region(s)
Polr2A
Encoded product / tool
Polr2A
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Polr2AIIt
      RpII215IIt
      Name Synonyms
      Secondary FlyBase IDs
        References (1)