FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fs(1)K1013
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General Information
Symbol
Dmel\fs(1)K1013
Species
D. melanogaster
Name
FlyBase ID
FBal0045665
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Eggs and embryos produced by homozygous females are completely dorsalised. The dorsal appendages are enlarged and completely encircle the anterior end of the egg. Less than 1% of the eggs are fertilised. The egg chamber in homozygous females first appears abnormal at stage 10, when all the follicle cells surrounding the anterior end of the oocyte begin to thicken and migrate centripetally. This gives the oocyte a 'bomb-like' appearance. The egg chamber is also shorter than normal. fs(1)K1013 heterozygous or homozygous females also homozygous for grk3, grk6, cniAA112 or Egfrt1 produce eggs with a ventralised phenotype. fs(1)K1013 homozygous females also heterozygous for Egfrt1 or cniAA112 produce eggs with a dorsalised phenotype. fs(1)K1013 homozygous females also heterozygous for grk3 produce eggs with a range of phenotypes, from that of fs(1)K1013 homozygotes to almost wild-type. Approximately 70% of the eggs produce an intermediate phenotype with two dorsal appendages that are located at the very anterior end of the egg. The embryos derived from these eggs also show a range of phenotypes, from a dorsalised to an almost wild-type cuticle. Rescue always occurs first at the posterior end of the embryo, with the cephalic structures being the last to differentiate normally and often being everted.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
fs(1)K1013
Name Synonyms
Secondary FlyBase IDs
    References (5)