FB2026_02 , released June 18, 2026
Allele: Dmel\gcm1308
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General Information
Symbol
Dmel\gcm1308
Species
D. melanogaster
Name
FlyBase ID
FBal0045762
Feature type
allele
Associated gene
Dmel\gcm
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Jones, 2014, Jones et al., 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: G75D.

(Jones, 2014)

Nucleotide substitution: G?A.

(Jones, 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:9,581,369..9,581,369 [-]
Nucleotide change:

G9581369A

Reported nucleotide change:

G?A

Amino acid change:

G75D | gcm-PA; G75D | gcm-PB

Reported amino acid change:

G75D

(Jones, 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      gcm1308 mutant embryos exhibit a reduced number of glial cells in the central nervous system. The pattern of missing glial cells appears to be random, with deficiencies in all CNS glial subtypes in each segment.

      gcmG78 mutant embryos exhibit a 51% reduction in the number of repo-positive glia.

      gcmG78/gcm1308 transheterozygotes exhibit a reduced number of glial cells in the embryonic central nervous system. The pattern of missing glial cells appears to be random, with deficiencies in all CNS glial subtypes in each segment.

      gcmG78/gcm1308 transheterozygous embryos exhibit a 53% reduction in the number of repo-positive glia.

      gcmΔP1/gcm1308 transheterozygotes exhibit a dramatic reduction in the number of glial cells in the embryonic central nervous system. These embryos display few glial cells near the midline along the longitudinal axon tracts, with the glial cells abnormally clustered along the lateral edges of the CNS.

      gcmΔP1/gcm1308 transheterozygous embryos exhibit a 76% reduction in the number of repo-positive glia.

      (Jones, 2014)

      Late stage embryos exhibit abnormal and occasionally missing longitudinal axon pathways and reduced number of glial cells.

      (Jones et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      gcm1308
      (Jones, 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)