FB2026_03 , released September 17, 2026
Allele: Dmel\hook492
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General Information
Symbol
Dmel\hook492
Species
D. melanogaster
Name
FlyBase ID
FBal0045890
Feature type
allele
Associated gene
Dmel\hook
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kramer and Phistry, 1999)
gamma ray
(Kramer and Phistry, 1999)
Progenitor genotype
Cytology
Description

Large insertion of DNA 3' of nucleotide 2330. This results in a C-terminally truncated protein.

(Kramer and Phistry, 1999)

7-8kb insertion.

(Stathakis et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
insertion
2L:19,031,456..19,031,457 [-]
Comment:

Reported as a large insertion 3' of position 2330 of GB:AF044925, resulting in C-terminal deletion of the polypeptide.

(Kramer and Phistry, 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies exhibit pleiotrophic phenotypes including abnormal bristle morphology (bristles often have a sharp bend and the tips are blunt instead of tapered) and light-dependent eye degeneration (degeneration is reduced but not completely suppressed in the dark).

      (Kramer and Phistry, 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      "ethyl methanesulfonate" was stated as tentative. "γ ray" was stated as tentative.

      (Kramer and Phistry, 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      hk492
      hook492
      Name Synonyms
      Secondary FlyBase IDs
        References (3)