FB2026_02 , released June 18, 2026
Allele: Dmel\hookC1
Open Close
General Information
Symbol
Dmel\hookC1
Species
D. melanogaster
Name
FlyBase ID
FBal0045891
Feature type
allele
Associated gene
Dmel\hook
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kramer and Phistry, 1999)
gamma ray
(Kramer and Phistry, 1999)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G2329T.

(Kramer and Phistry, 1999)

Amino acid replacement: ?546term.

(Kramer and Phistry, 1999)

Contains an aberration that eliminates an EcoRI site.

(Stathakis et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,031,458..19,031,458 [-]
Nucleotide change:

G19031458T

Amino acid change:

E546term | hook-PA

Comment:

Results in a 545aa polypeptide.

(Kramer and Phistry, 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies exhibit pleiotrophic phenotypes including abnormal bristle morphology (bristles often have a sharp bend and the tips are blunt instead of tapered) and light-dependent eye degeneration (degeneration is reduced but not completely suppressed in the dark).

      (Kramer and Phistry, 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      T.R.F. Wright.

      Comments
      Comments

      "ethyl methanesulfonate" was stated as tentative. "γ ray" was stated as tentative.

      (Kramer and Phistry, 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      hkC1
      hookC1
      Name Synonyms
      Secondary FlyBase IDs
        References (4)