FB2026_02 , released June 18, 2026
Allele: Dmel\l(2)gl+tMd
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General Information
Symbol
Dmel\l(2)gl+tMd
Species
D. melanogaster
Name
FlyBase ID
FBal0046049
Feature type
allele
Associated gene
Dmel\l(2)gl
Associated Insertion(s)
Carried in Construct
P{l(2)gl-24}
Key Links
Genomic Maps

Transgenic product class
inframe_deletion
(Jacob et al., 1987)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Jacob et al., 1987)
Mutagen
in vitro construct
(Merz et al., 1990, Gateff and Mechler, 1989, Jacob et al., 1987)
Progenitor genotype
l(2)gl+t13.1
(Merz et al., 1990, Jacob et al., 1987)
Carried in construct
P{l(2)gl-24}
Cytology
Description

Deletion of 3' end of 13.1kb fragment carrying the l(2)gl transcription unit, removing 1803 nucleotides from the 3' end of the 6kb l(2)gl transcript, and consequently removing 141 amino acids from the C terminal of the putative p127 protein.

(Jacob et al., 1987)
Allele components
Component
Use(s)
Regulatory region(s)
l(2)gl
Encoded product / tool
l(2)gl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
2L:11,963..22,471 [-]
Linked to:
EcoRI-StuI restriction fragment
Comment:

Deletion of 2.6kb StuI-EcoRI fragment of 3' end of l(2)gl+t13.1. Construct rescues l(2)gl mutant phenotype. Position of restriction fragment on reference sequence inferred by FlyBase curator.

(Merz et al., 1990, Gateff and Mechler, 1989, Jacob et al., 1987)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The timing of salivary gland histolysis is delayed compared to wild type in animals carrying l(2)gl+tMd. The appearance of cytoplasmic vacuoles (which precedes the histolysis in wild type) is also delayed, and the vacuoles persist over a longer period than normal without giving rise to cell lysis. The duration of larval, prepupal and pupal development is normal in these animals.

      (Farkas and Mechler, 2000)

      Suppresses the tumour phenotype of l(2)gl mutations.

      (Merz et al., 1990)

      Tumour phenotype of l(2)gl deficient animals is rescued, but viability is reduced, with about 60% of animals dying as pharate adults, unable to emerge from the pupal case.

      (Jacob et al., 1987)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      l(2)gl+t24
      (Farkas and Mechler, 2000)
      l(2)gl+tMd
      l(2)glt24
      Name Synonyms
      Secondary FlyBase IDs
        References (4)