FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mei-9RT1
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General Information
Symbol
Dmel\mei-9RT1
Species
D. melanogaster
Name
FlyBase ID
FBal0046111
Feature type
allele
Associated gene
Dmel\mei-9
Associated Insertion(s)
P{}mei-9RT1
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
PM hybrid dysgenesis
(Yamamoto et al., 1990)
P-element activity
(Sekelsky et al., 1995)
Progenitor genotype
Associated Insertion(s)
P{}mei-9RT1
Cytology
Description

Insertion of a 672bp P-element in the 5' untranslated region, 119bp upstream of the translation start site.

(Yildiz et al., 2004)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous females show a low frequency (28.6%) of region 3 cysts with two pro-oocytes (as assayed by c(3)G staining).

      (Joyce and McKim, 2009)

      mei-9RT1/mei-9A2 females show 2% X chromosome nondisjunction, compared to 0.33% in wild-type females. mei-9RT1/mei-9A2 females show a relatively small decrease in the level of crossing over along the left arm of chromosome 2 compared to wild type. mei-9RT1/mei-9A2 larvae are hypersensitive to ultraviolet light and nitrogen mustard.

      (Yildiz et al., 2004)

      Transheterozygotes in combination with mei-9a, mei-9b or mei-9A1 have normal frequencies of X chromosome non-disjunction. Homozygous females show a normal rate of recombination on the second chromosome.

      (Yamamoto and Wada, 1990)

      Methyl methanesulfonate sensitive, exposure causes lethality. Low frequency of nondisjunction.

      (Yamamoto et al., 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Transposase induced reversion demonstrates a P-element insertion is responsible for the mutant phenotype.

      (Yamamoto et al., 1990)

      Δ2-3 generated revertants confirm that the mutation is caused by insertion of a P-element.

      (Sekelsky et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mei-9RT1
      (Joyce and McKim, 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)