FB2026_03 , released September 17, 2026
Allele: Dmel\tipEhs.PF
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General Information
Symbol
Dmel\tipEhs.PF
Species
D. melanogaster
Name
heat shock construct of Feng
FlyBase ID
FBal0046580
Feature type
allele
Associated gene
Dmel\tipE
Associated Insertion(s)
Carried in Construct
P{hs-tipE}
Key Links
Transgenic product class
cDNA
(Feng et al., 1995)
wild_type
(Feng et al., 1995)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Feng et al., 1995)
wild_type
(Feng et al., 1995)
Mutagen
in vitro construct
(Feng et al., 1995)
Progenitor genotype
Carried in construct
P{hs-tipE}
Cytology
Description

An Hsp70 promoter drives the expression of a 2kb SspI fragment of tipE cDNA containing the whole open reading frame, 67bp 5' untranslated region and 558bp of 3' untranslated region.

(Feng et al., 1995)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
tipE
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Heat shock of adult transformants fails to rescue adult paralysis phenotype but completely rescues heat induced lethality. 1 hour heat pulse to transformants once a day throughout development until adult eclosion permanently cures the temperature induced paralysis phenotype. A combination of shift-up and shift-down experiments defines a developmental window during which expression of tipE+ is critical for the rescue, between 72 and 120 hours of postpuparium formation. A single heat shock within the critical phase results in partial rescue.

      (Feng et al., 1995)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tipEhs.PF
      Name Synonyms
      heat shock construct of Feng
      (Feng et al., 1995)
      Secondary FlyBase IDs
        References (1)