FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Frq1hs.PP
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General Information
Symbol
Dmel\Frq1hs.PP
Species
D. melanogaster
Name
heat shock construct of Pongs
FlyBase ID
FBal0048747
Feature type
allele
Associated gene
Dmel\Frq1
Associated Insertion(s)
Carried in Construct
P{TFrq}
Also Known As
Frqhs.PP
Key Links
Transgenic product class
cDNA
(Pongs et al., 1993)
wild_type
(Pongs et al., 1993)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Pongs et al., 1993)
wild_type
(Pongs et al., 1993)
Mutagen
in vitro construct
(Pongs et al., 1993)
Progenitor genotype
Carried in construct
P{TFrq}
Cytology
Description

Expression of a HindIII-EcoRI Frq1 cDNA fragment is driven by an Hsp70 promoter.

(Pongs et al., 1993)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Frq1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The total terminal length of the motor nerve endings in larvae carrying Frq1hs.PP and raised at 29[o]C is reduced compared to control larvae raised at 29[o]C. Single terminal branch length and the number of branches per ending are reduced. The phenotype is not altered if the larvae are also carrying T(1;Y)V7. There is a reduction in the number of boutons in larvae carrying Frq1hs.PP and raised at 29[o]C compared to control larvae raised at 29[o]C. The size of the small clear vesicles (SCVs) is not different from wild type and the size and arrangement of microtubules in interbouton axonal regions and of intraterminal mitochondria is normal.

      (Angaut-Petit et al., 1998)

      Shows enhanced facilitation of neurotransmitter release at larval neuromuscular junctions.

      (Rivosecchi et al., 1994)

      Heat induced expression of Frq1 promotes a 4-5 fold increase in the magnitude of facilitation of neurotransmitter release at motor nerve endings.

      (Pongs et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Frq1hs.PP
      Frqhs.PP
      (Angaut-Petit et al., 1998, Rivosecchi et al., 1994)
      Name Synonyms
      heat shock construct of Pongs
      (Pongs et al., 1993)
      Secondary FlyBase IDs
        References (3)