FB2026_03 , released September 17, 2026
Allele: Dmel\I-elementRTaseΔZ
Open Close
General Information
Symbol
Dmel\I-element\RTaseΔZ
Species
D. melanogaster
Name
FlyBase ID
FBal0048820
Feature type
allele
Associated gene
I-element\RTase
Associated Insertion(s)
Carried in Construct
P{W8-IΔZ}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Jensen et al., 1995)
Progenitor genotype
Carried in construct
P{W8-IΔZ}
Cytology
Description

Construct: An I-element (derived from the wIR3 I-element) marked with Ecol\lacZRT gene inserted in place of a 2.6kb fragment deleted from the second open reading frame. The deletion encompasses the previously identified reverse transcriptase, RNase H and 3' zinc finger domains.

(Jensen et al., 1995)
Allele components
Component
Use(s)
Encoded product / tool
I-element\RTase
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The level of sterility (i.e. the level of reactivity) of 'SF' females (sterile female progeny resulting from a dysgenic cross between strongly reactive transgenic females and inducers males) decreases within the first 12-14 generations after transgenesis. The transgenic lines have not acquired the inducer phenotype, female offspring from crosses between transgenic males and reactive females have low sterility. Low reactivity in the transgenic lines is maternally transmitted and resists repetitive crosses with a strongly reactive strain.

      (Jensen et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Defective I-element that cannot transpose. The reactivity level of the transgenic lines is tightly linked to the presence of the transgene, suggesting the transgene is a determinant of the reactivity level.

      (Jensen et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      I-element\RTaseΔZ
      I\TΔZ
      Name Synonyms
      Secondary FlyBase IDs
        References (1)