FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TlDB1
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General Information
Symbol
Dmel\TlDB1
Species
D. melanogaster
Name
FlyBase ID
FBal0049218
Feature type
allele
Associated gene
Dmel\Tl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

gain of function allele

Mutagen
    Nature of the Allele
    Allele class

    gain of function allele

    (Schneider et al., 1991)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Deletion from 2332bp to 2345bp in the extracellular domain of the protein. This results in a deleted and frameshifted protein.

    (Schneider et al., 1991)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    3R:26,839,611..26,839,624 [+]
    Comment:

    Mutation is a deletion leading to a frameshift and a premature stop codon. Position of mutation on reference sequence inferred by FlyBase curator based on author statement.

    (Schneider et al., 1991)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Embryos from heterozygous females are weakly ventralised at 29oC (50% of the embryos hatch into larvae, while the remainder do not undergo head involution and may not shorten the germ band), and moderately ventralised at 18oC. Females carrying TlDB1 in trans with a null allele of Tl produce dorsalised embryos.

        (Schneider et al., 1991)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Class II allele.

        (Schneider et al., 1991)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        TlDB1
        Name Synonyms
        Secondary FlyBase IDs
          References (1)